In this episode of A SkinDepth Convo, hosts Metaxia Dalikas, Francine Kagarakis, and Anna Kagarakis explore the powerful connection between internal health and skin health, revealing why true radiance starts from within.

From the role of the microbiome to liver function and cellular renewal, the conversation dives into how the body’s internal systems directly influence the skin’s appearance, resilience, and overall vitality. Drawing from their deep expertise and experience as founders of Lira Clinical, the hosts discuss the growing integration of wellness, esthetics, and medical science, and why modern skincare is no longer just skin-deep.

They are joined by special guest Dr. John Konstantin, who helps connect the dots between internal health and lasting, visible skin results. Together, they unpack how a holistic, inside-out approach is shaping the future of skincare and empowering both professionals and clients to think beyond the surface.

Tune in to discover how aligning internal wellness with advanced skincare can transform not just your skin, but your overall health.

Purely Clinical is more than an event; it’s an experience where education meets innovation and the future of skincare takes shape.

Over the past year, the Lira Clinical owners traveled across the globe delivering advanced education, protocol-driven learning, and exclusive first looks at upcoming innovations, straight to the treatment room. We’re recapping standout moments from the tour stops and unpacking what attendees truly gained, from interactive sessions and protocol development to testing prototypes and influencing product launches before they hit the market.

And of course, we’re teasing what’s ahead, because Purely Clinical 2026 is already shaping up to be something special. Join expert hosts and Lira Clinical founders Metaxia Dalikas and Francine Kagarakis for an inside look at the experience that’s redefining clinical education.

As we close the chapter of 2025 and reflect on all the things we accomplished, let's not forget the funny moments. Relive the laughs, bloopers, and real behind-the-scenes chaos that made 2025 unforgettable.