It's a new medicine made of old medicines! Jody reviews the mechanism of this new (?) option for treatment of major depressive disorder in adults.

References:

1) Auvelity Package Insert

2) Auvelity Review Article (Annals of Medicine & Surgery)

3) Auvelity Overview (OpenEvidence)

4) Physiology of NMDA Receptor (PubMed)

5) Pharmacology of Sigma-1 Receptor (PubMed)

6) Mucinex DM Label Information

Recent medical news followed by a review of pathophysiology, clinical manifestations, diagnosis, and treatment of myasthenia gravis.

News Articles:

1. New federal vaccine schedule (KFF): https://www.kff.org/other-health/the-new-federal-vaccine-schedule-what-changed/

2. HRT black box warning removal (FDA): https://www.fda.gov/news-events/press-announcements/hhs-advances-womens-health-removes-misleading-fda-warnings-hormone-replacement-therapy

3. More information about HRT warning label removal (Harvard Health): https://www.health.harvard.edu/womens-health/fda-removes-menopause-hormone-therapy-black-box-warnings

4. House votes to extend ACA subsidies (PBS): https://www.pbs.org/newshour/politics/in-a-rebuke-of-gop-leadership-house-heads-toward-vote-to-extend-health-care-subsidies

References:

1. Bird, S. J. Pathogenesis of myasthenia gravis. UpToDate. https://www.uptodate.com/contents/pathogenesis-of-myasthenia-gravis

2. Bird, S. J. Clinical manifestations of myasthenia gravis. UpToDate. https://www.uptodate.com/contents/clinical-manifestations-of-myasthenia-gravis

3. Bird, S. J. Diagnosis of myasthenia gravis. UpToDate. https://www.uptodate.com/contents/diagnosis-of-myasthenia-gravis

4. Bird, S. J. Overview of the treatment of myasthenia gravis. UpToDate. https://www.uptodate.com/contents/overview-of-the-treatment-of-myasthenia-gravis

Jody discusses ACA subsidies - what they are and why it matters that some of them are going away.

Resources:

1) Article on the Impact of Enhanced Subsidies Expiring (KFF)

2) News Article on the Republican Healthcare Plan (Reuters)

3) Interview About Subsidies Expiring (PBS)

4) Federal Poverty Level (healthcare.gov)

5) Reasons to Not Extend Enhanced Subsidies (CATO Institute)