『Infections & Cancer, Finasteride Side Effects, Blueberry Benefits, Vitamin D & Fertility, and CoQ10 : 1552』のカバーアート

Infections & Cancer, Finasteride Side Effects, Blueberry Benefits, Vitamin D & Fertility, and CoQ10 : 1552

Infections & Cancer, Finasteride Side Effects, Blueberry Benefits, Vitamin D & Fertility, and CoQ10 : 1552

無料で聴く

ポッドキャストの詳細を見る

【Amazonプライム会員限定】今ならプレミアムプランが4か月 月額99円。

10月19日まで。※適用条件あり
Infections Were Linked to About 1 in 8 Cancer Cases Worldwide A new global analysis estimates that infections were responsible for roughly 2.3 million new cancer cases in 2024, about 12% of all cancers worldwide. H. pylori and HPV were the largest contributors, followed by hepatitis B, Epstein-Barr virus, and hepatitis C. Host Dave Asprey explores how persistent infections can contribute to cancer through chronic inflammation, DNA damage, altered immune surveillance, and other biological pathways. He explains why this does not mean cancer is contagious or that infection inevitably leads to cancer, but argues that identifying, preventing, and treating infections such as H. pylori, hepatitis B, and hepatitis C can be an overlooked part of a long-term prevention strategy. Sources: -IARC: Global Burden of Cancer Attributable to Infections in 2024 -PubMed: Global Burden of Cancer Attributable to Infections in 2024 ~~~~ What We Really Know About Persistent Finasteride Side Effects Finasteride reduces the conversion of testosterone into DHT by inhibiting 5-alpha reductase, but that enzyme also participates in pathways involved in neuroactive steroids. Some former users report persistent sexual, cognitive, mood, and physical symptoms after stopping the drug, a collection of symptoms commonly called post-finasteride syndrome. Small studies have reported differences in neurosteroids, gene expression, androgen signaling, and peripheral nerve function among symptomatic former users, but these studies cannot establish that finasteride caused those changes or determine how common persistent symptoms are. Host Dave Asprey examines the evidence between the two extremes, neither dismissing persistent symptoms nor assuming that finasteride permanently damages everyone who takes it. European regulators have also recognized suicidal ideation as a possible adverse effect of oral finasteride, although its frequency remains unknown. Sources: -EMA: Finasteride and Dutasteride Safety Review -PubMed: Neuroactive Steroids After Finasteride Discontinuation PubMed: Neuroactive Steroids and Features in Post-Finasteride Patients PubMed: Differential Gene Expression in Post-Finasteride Syndrome ~~~ One Cup of Blueberries a Day Improved Measures of Vascular Function In a six-month randomized controlled trial involving 115 adults with metabolic syndrome, consuming the equivalent of one cup of blueberries per day improved endothelial function and a measure of arterial stiffness, while a half-cup dose did not produce the same effects. Host Dave Asprey explains why describing blueberries simply as “antioxidants” misses much of their biology. Anthocyanins and other polyphenols can interact with gut microbes and influence vascular, inflammatory, and nitric oxide-related signaling. He also examines a small smoothie experiment showing that the polyphenol oxidase found in bananas sharply reduced the circulating metabolites of certain flavan-3-ols, while emphasizing that the experiment did not prove bananas erase the benefits of blueberries. Sources: -American Journal of Clinical Nutrition: Blueberries and Cardiometabolic Function -Food & Function: Polyphenol Oxidase and Flavan-3-ol Bioavailability ~~~ Vitamin D Matters to Male Reproductive Biology, But It Is Not a Fertility Treatment Vitamin D receptors are present throughout the male reproductive system, and vitamin D signaling may influence processes involved in sperm motility and fertilization. Observational research has linked low vitamin D with poorer sperm motility, but clinical outcomes are less straightforward. In a randomized trial of 330 vitamin D-insufficient infertile men, supplementation raised vitamin D levels but did not improve overall semen parameters. Researchers observed potentially interesting signals involving spontaneous pregnancy and live birth among a subgroup of men with low sperm counts, but those findings require confirmation. Host Dave Asprey explains why correcting a vitamin D deficiency still makes sense while arguing that male fertility needs to be evaluated as a larger system involving metabolic health, sleep, heat exposure, medications, hormones, micronutrients, toxins, oxidative stress, and semen testing. Sources: -PubMed: Vitamin D Supplementation, Semen Quality and Live Birth Rate ~~~ CoQ10 Shows Why a Great Mechanism Does Not Guarantee a Great Treatment CoQ10 plays a central role in mitochondrial energy production and electron transport, making it an appealing candidate for diseases involving mitochondrial dysfunction, oxidative stress, and neuronal energy failure. Early biological reasoning and smaller studies looked promising, but larger clinical trials have repeatedly failed to show the expected neurological benefits. A randomized trial of 600 people with early Parkinson’s disease found no evidence that high-dose CoQ10 slowed disease progression, while a large Huntington’s disease trial was stopped early for futility. A ...
adbl_web_anon_alc_button_suppression_t1
まだレビューはありません