In this episode, Dr. Jones and Dr. Dan Kellams discuss the most important supplements for optimal health and weight loss. They highlight the importance of vitamin D, magnesium, and fish oil as core supplements. They also mention the significance of L-Carnitine for overweight individuals. The conversation provides insights into dosing, benefits, and potential side effects of these supplements. In this conversation, Dr. Dan Kellams discusses the use of supplements for weight loss and autoimmune diseases. He recommends using GLP-1 agonists and berberine for weight loss, as they improve insulin resistance and have anti-inflammatory properties. For autoimmune diseases, he explains that the immune system starts attacking the body's own tissues, leading to conditions like Hashimoto's disease and autoimmune diabetes. He emphasizes the importance of addressing the immune system and not just replacing hormones. Dr. Kellams also mentions the role of genetics, gut health, and triggering stressors in the development of autoimmune diseases. He recommends turmeric, resveratrol, vitamin D, and glutathione as supplements for autoimmune overweight patients. Lastly, he discusses the benefits of low-dose naltrexone (LDN) in modulating the immune system and improving T regulatory cell function.