In this episode of Rheuminations, host Adam J. Brown, MD, untangles the confusing serologies of lupus by learning about their discoveries from the beginning. He answers questions like what's the deal with immunofluorescence patterns, why does SSA/SSB have two names (Ro/LA), and is double-stranded DNA antibody really attracted to both strands?

· The story of antibodies in lupus. 3:27

· The "LE" factor. 10:11

· The changing fluorescent patterns of the staining of the nucleus/ENAs. 18:50

· The anti-Smith antibody. 24:51

· The mysteries of SSA and SSB. 28:52

· Double-stranded DNA. 36:32

· Crithidia luciliae. 40:30

We'd love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum.

References:

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Alspaugh MA, et al. Arthritis Rheum. 1976;doi:10.1002/art.1780190214

Aslpaugh MA, et al. J Clin Invest. 1975;doi:10.1172/JCI108007

Arana R, et al. J Clin Invest. 1967;doi:10.1172/JCI105677

Clark G, et al. J Immunol. 1969;PMED:4179557

Dubois EL, et al. Blood. 1957;doi:10.1182/blood.V12.7.657.657

Friou GJ, et al. J Immunol. 1958;doi:10.4049/jimmunol.80.4.324

Hargraves MM. Proc Staff Meet Mayo Clin. 1949;doi:10.1016/S0025-6196(25)08519-2

Haserick JR, et al. Am J Med Sci. 1950;doi:10.1097/00000441-195006000-00010

Rowell NR, et al. Arch Dermatol. 1963;doi:10.1001/archderm.1963.01590200064012

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Tsokos GC. J Immunol. 2006;doi:10.4049/jimmunol.176.3.1295

In this episode of Rheuminations, guest host Leonard H. Calabrese, DO, sits down with David Chernoff, MD, chief medical officer of SetPoint Medical, to discuss the vagus nerve and recent developments in immune mediated disease.

· The story of Kevin Tracey, MD. 5:08

· Going from cytokines to the vagus nerve to immune mediated inflammatory disease. 7:23

· The ups and downs of non-surgically implanted devices. 13:28

· The pivotal studies. 15:35

· Gadolinium MRI. 24:03

· The gut-brain immune axis. 29:35

We'd love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum. Leonard H. Calabrese, DO, can be reached at CALABRL@ccf.org. Follow him @LCalabreseDO.

In this episode of Rheuminations, host Adam J. Brown, MD, will walk you through the history of pleural effusions in rheumatoid arthritis. He discusses topics ranging from fascinating case studies to how pleural effusions are treated today.

· Diving into pleural effusions. 2:38

· What's in the fluid? 12:01

· When did pleural effusions become linked to RA? 15:18

· The glucose talk. 27:04

· Green effusions. 32:40

We'd love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum.