Jay L. Koyner, MD, is a Professor of Medicine in the Section of Nephrology at the University of Chicago where he also serves as the Medical Director of the Inpatient Dialysis Unit, Director of ICU Nephrology and the Associate Program Director of the Nephrology-Critical Care Fellowship. He hosted by Dr. Sola Aoun Bahous, Dean and Professor of the Department of Internal Medicine, Division of Nephrology at the Lebanese American University. Sola is also the Chair-Elect of the ISN Education Working Group. In this episode, Jay and Sola discuss the Acute Kidney Injury and the impact of Artificial Intelligence on detection. They will discuss Jay’s research in multi-modal deep learning models and his building of practical AKI Alerts, and how these innovations could change kidney care worldwide.

Clinical trial design in nephrology is evolving. In this episode, leading experts explore why a paradigm shift is needed from traditional biomarkers to patient-centered outcomes and practical strategies for advancing trial implementation. This conversation draws on insights from the ISN Consensus Meeting on Changing Paradigms of Studies in CKD (Vancouver, Nov 22-23, 2024) where clinicians, trialists, patient partners, regulators and industry scientists came together to rethink trial endpoints, outcomes and designs. Together, they discuss how reimagining kidney trials can generate more relevant, equitable, and actionable evidence for better kidney care worldwide.

Participants

Adeera Levin
Professor of Medicine, University of British Columbia, Canada, and Past-President of the International Society of Nephrology (ISN). Dr. Levin is a global leader in kidney health research, with extensive experience in chronic kidney disease (CKD) management, clinical trials, and international health system strengthening.

Jennifer Lees
Senior Clinical Lecturer and Honorary Consultant Nephrologist at the University of Glasgow, UK. Dr. Lees’ research focuses on improving patient outcomes in kidney disease through better trial design, biomarker evaluation, and translational approaches linking research to clinical care.

Kevin Weinfurt
Professor and Vice Chair of Faculty, Department of Population Health Sciences, Duke University School of Medicine, USA. Dr. Weinfurt is a behavioural scientist specializing in patient-reported outcomes (PROMs), ethical aspects of research participation, and improving the relevance of clinical trials to patients lived experiences.

Hiddo J. Lambers Heerspink
Professor of Clinical Trials and Personalized Medicine, University Medical Center Groningen, The Netherlands. Dr. Heerspink’s work bridges pharmacology, nephrology, and precision medicine, focusing on optimizing kidney and cardiovascular outcomes through innovative clinical trial design and biomarker discovery.

To read more, explore the related paper Changing Paradigms of Studies in Kidney Diseases published in Kidney International.

In the latest Episode of the Global Kidney Care podcast Augusto Cesar Soares dos Santos Junior interviews Rolando Claure-Del Granado, a Clinical Research Investigator at the Biomedical Research Institute (IIBISMED) at Facultad de Medicina, Universidad Mayor de San Simon (Cochabamba, Bolivia) and a visiting professor of the UNESP - São Paulo State University (Brazil).

This podcast is part of an ongoing series of resources for the ISN Academy dedicated to the topic of AI and Nephrology. Augusto and Rolando discuss how AI is changing the outlook for patients with AKI and how it can be utilized by nephrologists to treat those with AKI.