What does it look like when the Holy Spirit sends people out, and how can they still be full of joy when the world turns against them? In Lesson 13 of Fire Up!, "Advancements and Adversity Intertwined," Rob Pine and Cynthia follow the gospel from Antioch in Syria to Antioch in Pisidia as Paul's first missionary journey begins.

They start in Acts 11, where believers scattered by persecution plant the church at Antioch and Barnabas brings Saul in to help teach. In Acts 13:1–5, the Holy Spirit tells the church, while it is worshiping and fasting, to set apart Barnabas and Saul for the work He has called them to, with John Mark along to help. Rob and Cynthia also cover the false teacher in Cyprus, the governor who comes to faith there, and Paul's first full sermon in Pisidian Antioch. That leads into Romans 8:12–17 and what it means to be adopted children of God and co-heirs with Christ. Philippians 1:21 and James 1:2–3 help explain how the disciples could be joyful even after being persecuted and driven out.

Cynthia shares why accountability groups matter for leaders (Acts 20:28–31). She also talks through the myths and sayings she grew up with (1 Timothy 4), from black-cat bad luck to "God just wants you to be happy," and the time she answered that last one with a simple truth: God wants His people to be holy.

This episode is a companion to the Fire Up! study guide by Mark Schupbach, a 24-lesson study of the Holy Spirit from LifeMark Ministries.