In this episode of the College of Glycation, Professor Paul Reynolds explains why the liver sits at the center of systemic glycation. The same organ that clears advanced glycation end-products from the bloodstream is also the one that accumulates them when burdened with fat and inflammation, creating a self-reinforcing loop. Fructose is the key substrate: it bypasses the main regulatory brake of glycolysis, flooding the liver with both new fat (de novo lipogenesis) and methylglyoxal, the most aggressive endogenous glycating agent. RAGE, activated by AGEs and the danger signal HMGB1, is required for hepatic stellate cells to produce scar tissue; once collagen is deposited, AGE crosslinks make that scar resistant to breakdown. The 2023 renaming to metabolic dysfunction-associated steatotic liver disease (MASLD) correctly places insulin resistance and glycemic burden at the center of the diagnosis.Reynolds covers practical measurement tools (FIB-4, FibroScan, and supportive skin autofluorescence) and the specific weight-loss thresholds that matter: steatosis improves at 3–5 %, steatohepatitis at 7–10 %, and meaningful fibrosis regression mainly at 10 % or more. Fructose restriction produces rapid measurable benefits even without calorie reduction, and emerging histology data from GLP-1 therapies further support intervention while the process is still reversible. Fatty liver is a flux problem, not merely a storage problem—and every major point in the loop remains under your influence if addressed early enough.Paul’s favorite yerba mate: https://unicity.link/121f260bfe Yerbe mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds Full Metabolic System storefront: https://shop.unicity.com/paulreynolds Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount. Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20) Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)