In this episode of Endurance State of Mind, Anthony and Zach sit down with world-renowned aging researcher Dr. Matt Kaeberlein to separate longevity science from the hype surrounding peptides, anti-aging treatments, biological age tests, and performance optimization.

With more than 350 scientific publications and decades of experience studying the biology of aging, Dr. Kaeberlein brings a science-first perspective to an industry filled with bold promises and unanswered questions. From BPC-157 and TB-500 to GLP-1 medications, wearable technology, and the future of anti-aging research, this conversation explores what we know, what remains uncertain, and where people should be more skeptical.

We break down why being told that a treatment is natural doesn't automatically make it safe, why consumer biological age tests may not tell you what you think they do, and how to interpret the data coming from devices like WHOOP, Oura, Garmin, and continuous glucose monitors.

For endurance athletes, we also explore the relationship between performance and longevity, including injury prevention, recovery, nutrition, hormones, bone density, and the challenge of staying competitive as you get older. Dr. Kaeberlein shares his perspective on supplements, including creatine, vitamin D, omega-3s, NAD precursors, and emerging longevity compounds.

We also dive into the Dog Aging Project, an ambitious research initiative investigating whether rapamycin can extend the healthy lifespan of our canine companions and what studying aging in dogs could teach us about human longevity.

Whether you're a runner, ultrarunner, cyclist, biohacker, or simply someone who wants to stay healthy for as long as possible, this episode challenges you to think critically about the products, metrics, and protocols promising to slow the aging process.

The biggest takeaway? Be skeptical.

Because when it comes to longevity, understanding what we don't know can be just as important as understanding what we do.

In this episode, we cover:

• The biggest misconceptions about longevity and anti-aging science
• Peptides explained: BPC-157, TB-500, and the difference between FDA-approved drugs and experimental compounds
• Compounded peptides, product quality, contamination risks, and safety concerns
• Why biological age tests can be misleading
• WHOOP, Oura, Garmin, HRV, sleep scores, and continuous glucose monitors: which metrics deserve your attention?
• The difference between measurement accuracy and precision
• The relationship between endurance performance, lifespan, and healthspan
• How injury prevention, recovery, nutrition, and bone density affect athletes as they age
• Supplements and longevity: creatine, vitamin D, omega-3s, NAD precursors, and more
• What the Dog Aging Project could reveal about aging in humans
• Rapamycin and the ongoing search for interventions that improve healthy lifespan
• Why you should be skeptical of anyone promising a guaranteed path to longevity

Endurance State of Mind is about living the things other people only talk about. We're not interested in chasing every new trend just because it's popular. We're here to ask better questions, challenge assumptions, and learn from the people doing the work.

Some people talk about it. We're dumb enough to live it.

Subscribe to Endurance State of Mind for more conversations about running, ultrarunning, endurance training, sports science, recovery, and the mindset required to keep pushing your limits.

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