『Ep. 140: “T Cells Under Pressure” Featuring Dr. Martin Prlic』のカバーアート

Ep. 140: “T Cells Under Pressure” Featuring Dr. Martin Prlic

Ep. 140: “T Cells Under Pressure” Featuring Dr. Martin Prlic

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Guest: Dr. Martin Prlic is a Professor in the Vaccine and Infectious Disease Division at Fred Hutch Cancer Center. He discusses the challenges of studying human immunology and how his lab uses advanced single-cell technologies to understand T cell responses across healthy, inflamed, and tumor tissues. He also explores the biology of tissue-resident T cells, how inflammation shapes their function, and immune cell interactions at the maternal-fetal interface. Featured Products and Resources: Decorate your lab with a Nature Protocols wallchart outlining the production of therapeutic CAR T cells.Find high-quality antibodies and integrate them into your workflow! The Immunology Science Round Up lncRNA Regulates Gut Immunity – An IBD-associated long noncoding RNA promotes immune tolerance by enhancing regulatory T cell function and limiting inflammatory T cell responses. Trust in Research Antibodies – An investigation identified nearly 19,000 apparently manipulated antibody validation images across products sold by 15 research antibody vendors. Targeting Melanoma with mRNA – A Phase III trial found that a personalized mRNA neoantigen therapy combined with KEYTRUDA improved recurrence-free and distant metastasis-free survival compared with KEYTRUDA alone after melanoma surgery. Beyond Shingles Prevention – A recombinant shingles vaccine was associated with a lower long-term risk of several cardiovascular outcomes, supporting further studies of its potential cardioprotective effects. Engineering Myeloid Immunotherapy – Expandable granulocyte-monocyte progenitors provide a scalable platform for engineering macrophages that can target blood and solid tumors. CAR T Cells Meet Glioblastoma – Responses to CAR T cell therapy for glioblastoma are associated with the surrounding immune environment, with NK cells linked to response and regulatory T cells and suppressive myeloid cells linked to resistance. Image courtesy of Dr. Martin Prlic Subscribe to our newsletter! Never miss updates about new episodes. Subscribe
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