Ep. 11: The Science Behind Psychedelics
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Ep. 11: The Science Behind Psychedelics
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Psychedelic-assisted therapy is rapidly transitioning from experimental research into mainstream clinical discussion, making it increasingly important for mental health professionals to understand the science behind these compounds. In this episode of Psychopharmacology Today, Dr. Judi Steinman explores the pharmacology of classic psychedelics (including LSD, psilocybin, mescaline, MDMA, ketamine, and related compounds) and explains how these substances interact with serotonin receptors, glutamate signaling, and broader neural networks involved in perception, cognition, and emotional processing.
Drawing on her background as a pharmacologist and educator, Dr. Steinman examines the biochemical similarities and differences among psychedelic compounds, emerging research into their therapeutic potential for conditions such as depression and PTSD, and the mechanisms that may underlie their profound psychological effects. She also discusses CYP450 metabolism, clinically significant drug interactions, the risk of serotonin syndrome, evolving FDA research guidance, and why prescribing clinicians must understand both the opportunities and limitations of these therapies as the field continues to evolve.