n this episode of Endurance State of Mind, Anthony and Zach sit down with David Slowick to recap his experience running the No Business 100 ultramarathon, a challenging 100-mile trail race through the rugged mountains and technical terrain of Tennessee and Kentucky. David returns to the podcast to break down the race from start to finish, sharing what went right, what went wrong, and the lessons he learned from one of the toughest challenges in ultrarunning.

Preparing for a 100-mile ultramarathon is difficult under the best circumstances, but David's training came with the added challenges of family life, a newborn, and balancing work with endurance training. He explains how he adapted his training schedule with early-morning runs, shorter sessions, and two-a-days while trying to arrive at the starting line ready for 100 miles. He also discusses running a 50K just six days before the race and how his preparation shaped his expectations going into No Business 100.

Once the race began, David quickly learned that previous ultramarathon experience doesn't guarantee a smooth day on the trails. He discusses the steep climbs, technical terrain, river crossings, nighttime running, navigation challenges, and the importance of having the right equipment. From headlamp problems and getting lost to struggles with nutrition, fatigue, and difficult moments on the course, David explains how small mistakes can become major problems over the course of 100 miles.

The conversation also explores the mental side of ultramarathon racing. David reflects on the low points that tested his willingness to continue, the importance of adjusting expectations when a race doesn't go according to plan, and how his crew, pacers, and wife Shelby helped him keep moving when things became difficult. He shares why problem-solving, adaptability, and support can be just as important as physical fitness when attempting a 100-mile race.

Anthony, Zach, and David also discuss race planning, pacing strategy, nutrition, gear selection, training for ultra-distance events, and the differences between preparing for a 50K, a 50-miler, and a 100-mile ultramarathon. David's experience at No Business 100 offers an honest look at the reality of ultrarunning: you can prepare for months, but once you're on the course, you have to be ready to adapt.

Whether you're training for your first ultramarathon, preparing for a 100-mile race, building your endurance, or simply interested in the realities of ultra-distance running, this episode is full of practical lessons and honest conversation about the physical and mental demands of endurance sports.

Topics covered in this episode:

• No Business 100 ultramarathon race recap
• Running 100 miles on technical trails in Tennessee and Kentucky
• Training for a 100-mile ultramarathon while balancing family and work
• Ultramarathon pacing, race strategy, and managing expectations
• Trail running gear, headlamps, and nighttime navigation
• Nutrition, hydration, and problem-solving during an ultra
• Getting lost and overcoming setbacks during a 100-mile race
• Mental toughness, low points, and the decision to keep going
• The role of pacers, crew members, and family in ultramarathon racing
• Lessons learned from previous races and applying them to future ultras

Endurance State of Mind: Some people talk about endurance. We're dumb enough to live it.

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In this episode of Endurance State of Mind, Anthony and Zach sit down with world-renowned aging researcher Dr. Matt Kaeberlein to separate longevity science from the hype surrounding peptides, anti-aging treatments, biological age tests, and performance optimization.

With more than 350 scientific publications and decades of experience studying the biology of aging, Dr. Kaeberlein brings a science-first perspective to an industry filled with bold promises and unanswered questions. From BPC-157 and TB-500 to GLP-1 medications, wearable technology, and the future of anti-aging research, this conversation explores what we know, what remains uncertain, and where people should be more skeptical.

We break down why being told that a treatment is natural doesn't automatically make it safe, why consumer biological age tests may not tell you what you think they do, and how to interpret the data coming from devices like WHOOP, Oura, Garmin, and continuous glucose monitors.

For endurance athletes, we also explore the relationship between performance and longevity, including injury prevention, recovery, nutrition, hormones, bone density, and the challenge of staying competitive as you get older. Dr. Kaeberlein shares his perspective on supplements, including creatine, vitamin D, omega-3s, NAD precursors, and emerging longevity compounds.

We also dive into the Dog Aging Project, an ambitious research initiative investigating whether rapamycin can extend the healthy lifespan of our canine companions and what studying aging in dogs could teach us about human longevity.

Whether you're a runner, ultrarunner, cyclist, biohacker, or simply someone who wants to stay healthy for as long as possible, this episode challenges you to think critically about the products, metrics, and protocols promising to slow the aging process.

The biggest takeaway? Be skeptical.

Because when it comes to longevity, understanding what we don't know can be just as important as understanding what we do.

In this episode, we cover:

• The biggest misconceptions about longevity and anti-aging science
• Peptides explained: BPC-157, TB-500, and the difference between FDA-approved drugs and experimental compounds
• Compounded peptides, product quality, contamination risks, and safety concerns
• Why biological age tests can be misleading
• WHOOP, Oura, Garmin, HRV, sleep scores, and continuous glucose monitors: which metrics deserve your attention?
• The difference between measurement accuracy and precision
• The relationship between endurance performance, lifespan, and healthspan
• How injury prevention, recovery, nutrition, and bone density affect athletes as they age
• Supplements and longevity: creatine, vitamin D, omega-3s, NAD precursors, and more
• What the Dog Aging Project could reveal about aging in humans
• Rapamycin and the ongoing search for interventions that improve healthy lifespan
• Why you should be skeptical of anyone promising a guaranteed path to longevity

Endurance State of Mind is about living the things other people only talk about. We're not interested in chasing every new trend just because it's popular. We're here to ask better questions, challenge assumptions, and learn from the people doing the work.

Some people talk about it. We're dumb enough to live it.

Subscribe to Endurance State of Mind for more conversations about running, ultrarunning, endurance training, sports science, recovery, and the mindset required to keep pushing your limits.

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