GLP-1s are everywhere. But are they the only medical weight loss intervention worth considering? On today’s episode, Dr. George Fielding - a pioneer of laparoscopic adjustable band surgery and a patient of the procedure himself - offers an insider’s look at the world of weight loss surgeries. How do these surgeries work? Who are they really for? And how should we think about them alongside the surge of GLP-1 medications? We also dig into the stigmas people face when trying to lose weight with medical support, and the biggest misconceptions around obesity.

Links to resources mentioned in this episode:

Genomics reveals eleven obesity endotypes with distinct biological and phenotypic signatures

Obesity Drugs May Drop to as Little as $149 a Month

The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors

Associations of Hysterectomy, Oophorectomy, and Hormone Replacement Therapy With the Risk of Type 2 Diabetes Mellitus in Postmenopausal Women

Note: In this show, we use “women” as shorthand for people with XX chromosomes. We understand sex and gender are more complex, and acknowledge the experiences we describe reach beyond that word.

See omnystudio.com/listener for privacy information.

Almost two-thirds of people diagnosed with Alzheimer’s are women. Shifting hormones make us especially vulnerable. But what if there were ways to lower your risk? Preventive neurologist Dr. Richard Isaacson believes nearly half of dementia cases can be avoided. He shares how to know if you’re at risk for Alzheimer’s and what steps to take for better long-term brain health.

Links to resources mentioned in this episode:

Individualized clinical management of patients at risk for Alzheimer’s dementia

Structured vs Self-Guided Multidomain Lifestyle Interventions for Global Cognitive Function

A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial

Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission

Clinical Application of APOE in Alzheimer's Prevention: A Precision Medicine Approach

Menopause impacts human brain structure, connectivity, energy metabolism, and amyloid-beta deposition

Association of Reproductive History With Brain MRI Biomarkers of Dementia Risk in Midlife

Effect of Intensive vs Standard Blood Pressure Control on Probable Dementia: A Randomized Clinical Trial

evoke and evoke+: design of two large-scale, double-blind, placebo-controlled, phase 3 studies evaluating efficacy, safety, and tolerability of semaglutide in early-stage symptomatic Alzheimer's disease

Sex-Driven Differences in the Effectiveness of Individualized Clinical Management of Alzheimer's Disease Risk

Sex-driven modifiers of Alzheimer risk: A multimodality brain imaging study

The Institute for Neurodegenerative Diseases (IND)

Retain Your Brain

Note: In this show, we use “women” as shorthand for people with XX chromosomes. We understand sex and gender are more complex, and acknowledge the experiences we describe reach beyond that word.

See omnystudio.com/listener for privacy information.

Why does your body start “shape shifting” in midlife, even if you’re doing everything “right”? And what’s really behind all the GLP-1 buzz? Endocrinologist and weight-management specialist Dr. Beverly Tchang explains the science behind midlife metabolism, why BMI alone doesn’t tell the full story, what GLP-1s actually do in the body, and what women should know before considering these treatments.

Links to resources mentioned in this episode:

Dr. Beverly Tchang’s Professional Disclosures

SWAN Study (Study of Women’s Health Across the Nation)

HOMA-IR Calculator (for assessing insulin resistance)

STEP 1 Trial – Semaglutide for weight management

SURMOUNT-1 Trial – Tirzepatide for weight management

Note: In this show, we use “women” as shorthand for people with XX chromosomes. We understand sex and gender are more complex, and acknowledge the experiences we describe reach beyond that word.

See omnystudio.com/listener for privacy information.