David Stellwagen: Tumor Necrosis Factor, Homeostatic Synaptic Plasticity, and Stress Responses
カートのアイテムが多すぎます
カートに追加できませんでした。
ウィッシュリストに追加できませんでした。
ほしい物リストの削除に失敗しました。
ポッドキャストのフォローに失敗しました
ポッドキャストのフォロー解除に失敗しました
David Stellwagen: Tumor Necrosis Factor, Homeostatic Synaptic Plasticity, and Stress Responses
-
ナレーター：
-
著者：
Tumor necrosis factor (TNF) is a pro-inflammatory cytokine known for its detrimental effects on tissues in disease such as rheumatoid arthritis, Crohn's disease, and skin psoriasis. However, TNF has normal functions in the absence of inflammation. TNF is produced in low amounts by cells in the brain – particularly microglia and astrocytes – and neurons can respond to TNF in several ways. In this episode I talk with McGill University neuroscientist David Stellwagen about evidence that TNF plays important roles in regulating rapid synaptic adaptations to neural network activity. Such effects of TNF on synaptic plasticity may regulate adaptive changes in neural circuits and consequent changes in behaviors. We also talk about work in my lab showing that TNF can protect neurons against damage and degeneration under certain conditions.
LINKS
Stellwagen Laboratory: https://www.stellwagenlab.org/
Review article: https://www.nature.com/articles/s41380-026-03861-4
Original research articles:
https://www.nature.com/articles/nature04671
https://pmc.ncbi.nlm.nih.gov/articles/PMC9734040/pdf/41380_2022_Article_1737.pdf
https://pmc.ncbi.nlm.nih.gov/articles/PMC10993029/pdf/jneuro-44-e2278222024.pdf
https://pmc.ncbi.nlm.nih.gov/articles/PMC40978/pdf/pnas01498-0326.pdf
https://www.nature.com/articles/nm0796-788
https://onlinelibrary-wiley-com.proxy1.library.jhu.edu/doi/epdf/10.1002/%28SICI%291098-2396%28200002%2935%3A2%3C151%3A%3AAID-SYN8%3E3.0.CO%3B2-P