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Daniel Oliver: The Science of Reversing Age-Related Disease

Daniel Oliver: The Science of Reversing Age-Related Disease

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What if we could reverse the damage caused by age-related disease instead of simply managing its symptoms? In this episode of Entrepreneur Rx, host John Shufeldt sits down with Daniel Oliver, CEO and Co-founder of Rejuvenate Bio, a Jetstream Venture Fund portfolio company, to explore the science behind age-related disease, the potential of gene therapy, and what it takes to turn groundbreaking research into treatments for both animal and human health. This success has lead to one of the leading crowdfunding equity campaigns.Rejuvenate Bio grew out of George Church’s lab at Harvard Medical School, where research into the biology of aging opened the door to a bigger question: instead of treating age-related diseases one at a time, could we target the underlying changes that drive them? Daniel explains the company’s work across heart failure, kidney failure, metabolic dysfunction, and epigenetic reprogramming. Daniel and John also dig into Rejuvenate Bio’s strategy of developing therapies for both companion animals and humans. Its most advanced program is targeting mitral valve disease in dogs, while its human program moves toward clinical development. Daniel explains why dogs can be a powerful model for age-related disease and how animal health may provide a faster path for translating aging science into real-world therapies. Beyond the science, Daniel shares his unconventional journey from mechanical engineering and aerospace to Harvard Business School, entrepreneurship, and biotech. He and John discuss why breakthrough ideas often emerge at the intersection of different disciplines, and they get candid about the pressure of startup life and why the “never sleep, always hustle” mentality can make founders worse leaders. About Daniel Oliver: Daniel Oliver is Co-founder and CEO of Rejuvenate Bio, a spinout of George Church’s Lab at Harvard Medical School focused on targeting the drivers of age-related disease through novel gene therapies. Prior to Rejuvenate Bio, Daniel was awarded a Blavatnik Fellowship, during which he co-founded Voxel8. Voxel8 was named one of the top innovations at CES and one of the 50 most innovative companies by MIT Technology Review. Daniel received his MBA from Harvard Business School and holds degrees in Mechanical Engineering and Business from the California Institute of Technology. About Rejuvenate Bio: Rejuvenate Bio is a George Church spinout with backing from Merck and leading VCs developing one-time gene therapies that target the root causes of age-related disease, beginning in companion animals and expanding to humans. The company was the first to demonstrate lifespan extension using epigenetic reprogramming and is advancing a breakthrough cardiovascular platform built around a single-dose therapy that restores youthful levels of a critical age-declining soluble protein. Preclinical data show reversal of heart damage and durable metabolic reset, positioning the program as a potential long-term alternative to chronic therapies such as GLP-1s. About Xcellerant Ventures: Xcellerant is a venture capital firm investing in innovative companies across healthcare, technology, defense, and other emerging industries.About Jetstream Venture Fund: Jetstream is an interval fund that provides investors access to venture opportunities across multiple stages, with a $5,000 minimum and no carried interest. Disclosure for Jetstream: Investors should carefully consider the investment objectives, risks, charges, and expenses of the Fund before investing. The prospectus contains this and other information about the Fund and can be obtained by emailing jetstream@sweaterfunds.com or by visiting www.jvf.vc. Please read the prospectus carefully before investing. About Pitch Deck Analysis: Pitch Deck Analysis reviews your deck like an investor would, with scoring, feedback, and recommendations on what to improve before you pitch. Use code EntrepreneurRx for a free Founder Pack with five free runs.
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