After U.S. Navy sailor Andrew Muns disappears in 1968, the Navy claims that Muns went AWOL from his ship. But his sister works tirelessly for over 30 years to prove that Muns was really killed. And DNA surreptitiously gathered from a cigarette butt helps detectives to unravel a 20-year-old case of rape and murder.

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In November of 1988, 27-year-old Enietra Margette is walking to a party in South Los Angeles, when a neatly dressed man in a souped-up orange pinto offers her a ride. Soon after getting into the car, the driver, Lonnie Franklin, shoots the young passenger point blank in the chest. By this time, he had already committed a string of grisly murders in the city. Enietra recounts in her own words her resilience and keen insights that helped her outwit the would-be murderer.

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In December 1985, when human bones are discovered in the woods, it puts an end to the search for missing teen David Reed. David's disappearance shook a small town, and skull fractures point to murder; but it will be decades before investigators can find his killer.

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Guns found dumped in a pond outside of Atlantic City, N.J., help police to solve the 15-year-old murder of Detroit cab company owner. And the rape and murder of an Atlanta TV station receptionist goes cold for 20 years before the FBI's Combined DNA Index System (CODIS) links a man with three prior burglary convictions to the crime.

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In August of 1978, 14-year-old Lisa Gilbert and her 13-year-old brother, Randy, were attacked by a stranger in their newly built home in Lansing, Michigan. Their attacker was 23-year-old Don Miller. Miller was also a suspect in multiple local disappearance cases spanning the Lansing/East Lansing area. Lisa and Randy each recount Don Miller’s attacks on them; East Lansing Detective, Rick Westgate offers insight into the investigation; and author, Rod Sadler provides additional commentary.

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In June, 1985, a 20-year-old ‘Sucker Day’ festival queen is found brutalized. The small community of Nixa, Missouri are certain that her blood is on the hands of a local, wealthy businessman. But, after 25 years, DNA reveals the true killer.

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On a summer night in 1987 a mother worries and waits for her 19-year-old daughter to come home. But Diana never comes home and she's found raped and strangled near the Hudson River. Investigators suspect her friend, Michael because his alibi is shaky and witnesses place his truck near the crime scene. Trouble is, he passes a polygraph and his DNA is no match. Nevertheless, Michael remains the chief suspect for 17 years, until DNA fingers another man who offers a chilling story of Diana's last breath. Then, a young family's life is shattered when a San Antonio interior design shop becomes a crime scene. In 1983, a young mother is raped and murdered at work. The crime remains unsolved for two decades. Then in 2003 detectives reopen the case pegging their hopes on DNA. But when the evidence turns up missing, detectives worry this case could be over before it starts.

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In 1999, Cynthia Vigil was abducted and held captive for 3 horrific days in Truth or Consequences, NM. Cynthia managed to escape and report her experience to the police. Once her kidnapper, David Parker Ray, is taken to jail, an intense FBI investigation revealed that he has an entire torture chamber unlike anything investigators have ever seen called The Toy Box. Cynthia's heroic escape opens up a Pandora's box of kidnappings, torture and murder. In this episode, Cynthia recounts her incredible act of survival and strength and describes how she put an end to the horror brought on by The Toy Box Killer.

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