Life sciences are at a critical inflection point, where scientific innovation, regulatory demands, and patient expectations converge with advances in data and artificial intelligence, positioning IT as a central driver of faster and more effective drug discovery and clinical development.

This week, Dave and Rob continue with part 2 off the Life Sciences mini-series with Dr. Alex Zhavoronkov founder and CEO of Insilico Medicine to exploring how drug discovery and clinical development can become faster and more effective, and the role of AI in that process.

TLDR

00:40 – Introduction
01:00 – Hang out: Kill Bill Vol. 1 & 2
03:07 – Dig in: Life Sciences mini-series, Part 2
06:43 – Conversation with Dr Alex Zhavoronkov
42:12 – The future of AI in drug discovery and a new paradigm for pharma

Guest

Dr. Alex Zhavoronkov: https://www.linkedin.com/in/zhavoronkov/

Hosts

Dave Chapman: https://www.linkedin.com/in/chapmandr/

Esmee van de Giessen: https://www.linkedin.com/in/esmeevandegiessen/

Rob Kernahan: https://www.linkedin.com/in/rob-kernahan/

Production

Marcel van der Burg: https://www.linkedin.com/in/marcel-vd-burg/

Dave Chapman: https://www.linkedin.com/in/chapmandr/

Sound

Ben Corbett: https://www.linkedin.com/in/ben-corbett-3b6a11135/

Louis Corbett: https://www.linkedin.com/in/louis-corbett-087250264/

'Realities Remixed' is an original podcast from Capgemini

Innovation isn’t about funding, it’s about how organisations are built and led. Progress comes from cutting bureaucracy, empowering mission-led teams, and asking the right questions to unlock bold breakthroughs.

This week, Dave, Esmee and Rob are joined again by André Loesekrug-Pietri, Chair and Scientific Director of the Joint European Disruptive Initiative (JEDI, Europe’s ARPA) to explore how Europe can turn moonshot ambitions into reality by building the right people, culture and operating models for future-shaping organisations.

TLDR

00:41 – Introduction
01:14 – Hang out: Esmee returns and the missing API has been found!
05:14 – Dig in: Staying in step with global innovation
12:57 – Conversation with André Loesekrug-Pietri
1:02:26 – Roland Garros tennis, and unlocking creative energy

Guest

Andre Loeskrug-Petri: https://www.linkedin.com/in/andrepietri/

X: @eurojedi
www.jedi.foundation

Hosts

Dave Chapman: https://www.linkedin.com/in/chapmandr/

Esmee van de Giessen: https://www.linkedin.com/in/esmeevandegiessen/

Rob Kernahan: https://www.linkedin.com/in/rob-kernahan/

Production

Marcel van der Burg: https://www.linkedin.com/in/marcel-vd-burg/

Dave Chapman: https://www.linkedin.com/in/chapmandr/

Sound

Ben Corbett: https://www.linkedin.com/in/ben-corbett-3b6a11135/

Louis Corbett: https://www.linkedin.com/in/louis-corbett-087250264/

'Realities Remixed' is an original podcast from Capgemini

Realities Remixed, formerly known as Cloud Realities, launches a new season exploring the intersection of people, culture, industry and tech.

Life sciences are at a turning point, where scientific innovation, regulatory pressure, and patient expectations collide with unprecedented advances in data, AI, and digital platforms. IT is no longer a supporting function but a critical driver of how therapies are discovered, developed, scaled, and delivered safely and at speed.

This week, Dave and Rob kick off the Life Sciences mini‑series with Thorsten Rall, Global Industry Lead for Life Sciences at Capgemini, to exploring the current state of the sector, the key themes shaping the episodes ahead, and what it takes to drive better patient outcomes.

TLDR

00:30 – Introduction to Life Sciences and co‑host Thorsten Rall
04:37 – Hang‑out: Navigating Waterloo Station
07:50 – Deep dive with Thorsten Rall into the Life Sciences landscape
28:03 - What are the main challenges in the sector and main themes
45:31 – BBQ season is starting

Hosts

Dave Chapman: https://www.linkedin.com/in/chapmandr/

Esmee van de Giessen: https://www.linkedin.com/in/esmeevandegiessen/

Rob Kernahan: https://www.linkedin.com/in/rob-kernahan/

with co-host Thorsten Rall: https://www.linkedin.com/in/thorsten-alexander-rall-b232185/

Production

Marcel van der Burg: https://www.linkedin.com/in/marcel-vd-burg/

Dave Chapman: https://www.linkedin.com/in/chapmandr/

Sound

Ben Corbett: https://www.linkedin.com/in/ben-corbett-3b6a11135/

Louis Corbett: https://www.linkedin.com/in/louis-corbett-087250264/

'Realities Remixed' is an original podcast from Capgemini

Realities Remixed, formerly known as Cloud Realities, launches a new season exploring the intersection of people, culture, industry and tech.

Today’s most pressing challenges arise from the collision of rapid technological change with deepening economic inequality, weakening democratic systems, geopolitical instability and accelerating climate pressure, leaving world leaders wrestling with how to govern and solve these deeply interconnected crises.

This week, Dave, Esmee and Rob are joined by Dex Hunter-Torricke, Founder & President The Center for Tomorrow to explore how tech can solve world macro issues.

TLDR

00:33 – Introduction
00:40 – Hang out: The Boys on Amazon Prime final episode (spoilers)
06:02 – Dig in: How to solve world macro issues?
07:45 – Conversation with Dex Hunter-Torricke
44:52 – Writing a book and meeting world leaders

Guest

Dex Hunter-Torricke: https://www.linkedin.com/in/dextb/
https://www.centerfortomorrow.com/

Hosts

Dave Chapman: https://www.linkedin.com/in/chapmandr/

Esmee van de Giessen: https://www.linkedin.com/in/esmeevandegiessen/

Rob Kernahan: https://www.linkedin.com/in/rob-kernahan/

Production

Marcel van der Burg: https://www.linkedin.com/in/marcel-vd-burg/

Dave Chapman: https://www.linkedin.com/in/chapmandr/

Sound

Ben Corbett: https://www.linkedin.com/in/ben-corbett-3b6a11135/

Louis Corbett: https://www.linkedin.com/in/louis-corbett-087250264/

'Realities Remixed' is an original podcast from Capgemini

Starting an AI company is all about spotting a real problem and using AI to solve it in a smarter, faster way than what’s out there today. It’s less about having the perfect idea and more about starting focused, learning fast, and building something people actually want.

This week, Dave, Esmee, and Rob are joined by Gijs van de Nieuwegiessen and Tijn van Daelen, founders of One Horizon AI, to explore what it really takes to start and build an AI‑native company

TLDR

00:32 – Introduction
00:55 – Hang out: Why Dutch names can be a real tongue-twister
02:00 – Dig in: Exploring how an AI-native culture fits with human-to-human interaction
13:35 – Deep dive with Gijs van de Nieuwegiessen and Tijn van Daelen
1:01:54 – Following AI: Bloopers, reflections, and field hockey with the kids

Guest

Gijs van de Nieuwegiessen: https://www.linkedin.com/in/nieuwegiessen/
Tijn van Daelen: https://www.linkedin.com/in/tijn-van-daelen-495986131/
Open source repo: https://github.com/onehorizonai/ink

Hosts

Dave Chapman: https://www.linkedin.com/in/chapmandr/

Esmee van de Giessen: https://www.linkedin.com/in/esmeevandegiessen/

Rob Kernahan: https://www.linkedin.com/in/rob-kernahan/

Production

Marcel van der Burg: https://www.linkedin.com/in/marcel-vd-burg/

Dave Chapman: https://www.linkedin.com/in/chapmandr/

Sound

Ben Corbett: https://www.linkedin.com/in/ben-corbett-3b6a11135/

Louis Corbett: https://www.linkedin.com/in/louis-corbett-087250264/

'Realities Remixed' is an original podcast from Capgemini

Open Source is giving AI a real boost, making it easier and faster for organisations to build and experiment with new ideas. As adoption grows, these open ecosystems are helping businesses move quicker, stay flexible, and unlock value with more confidence.

This week, Dave, Esmee, and Rob are joined by Richard Harmon, VP & Global Head of Financial Services at Red Hat to explore how Open Source is shaping AI, from mainframes to Kubernetes, and from regulation and sovereignty to a future of AI agents writing code.

TLDR

00:25 – Introduction
00:52 – Hangout: Deep democracy training and “what instrument are you?”
03:19 – Dig in: Open‑source culture and AI, do they complement each other?
10:02 – Conversation with Richard Harmon
51:12 – Sitting in the chair and trying to keep up with AI

Guest

Richard Harmon: https://www.linkedin.com/in/richardlaurenharmon/

Hosts

Dave Chapman: https://www.linkedin.com/in/chapmandr/

Esmee van de Giessen: https://www.linkedin.com/in/esmeevandegiessen/

Rob Kernahan: https://www.linkedin.com/in/rob-kernahan/

Production

Marcel van der Burg: https://www.linkedin.com/in/marcel-vd-burg/

Dave Chapman: https://www.linkedin.com/in/chapmandr/

Sound

Ben Corbett: https://www.linkedin.com/in/ben-corbett-3b6a11135/

Louis Corbett: https://www.linkedin.com/in/louis-corbett-087250264/

'Realities Remixed' is an original podcast from Capgemini

The SaaSpocalypse marks the end of traditional CRM with manual data entry, rigid interfaces, and seat‑based software no longer make sense in an AI‑driven world. Success now depends on outcome‑focused plumbing: intelligent orchestration that delivers results, not screens.

This week, Dave, Esmee, and Rob are joined by Hannah Datz, Americas Vice President of CRM at ServiceNow, to unpack the major announcements from ServiceNow Knowledge 2026 in Las Vegas and explore how AI is accelerating the SaaSpocalypse and driving a fundamental shift in the future of CRM.

TLDR

00:34 – Introduction
00:54 – Hang out: Happy Password Day and emerging threats
06:46 – Conversation with Hannah Datz
57:20 – From tennis excitement to the best burger ever

Guest

Hannah Datz: https://www.linkedin.com/in/hannahdatz/

Hosts

Dave Chapman: https://www.linkedin.com/in/chapmandr/

Esmee van de Giessen: https://www.linkedin.com/in/esmeevandegiessen/

Rob Kernahan: https://www.linkedin.com/in/rob-kernahan/

Production

Marcel van der Burg: https://www.linkedin.com/in/marcel-vd-burg/

Dave Chapman: https://www.linkedin.com/in/chapmandr/

Sound

Ben Corbett: https://www.linkedin.com/in/ben-corbett-3b6a11135/

Louis Corbett: https://www.linkedin.com/in/louis-corbett-087250264/

'Realities Remixed' is an original podcast from Capgemini

AI is only as strong as the data beneath it, and as it moves into the core of the enterprise, fragmented, duplicated, and poorly governed data is no longer hidden in the background, it’s amplified, exposed, and impossible to ignore.

This week, Dave, Esmee, and Rob are joined by Edward Calvesbert, VP Product Management for IBM watsonx AI & Data Platform, to dig into the foundations of enterprise AI, from data silos and the SaaSpocalypse to lakehouse architectures and agent‑driven workflows.

TLDR

00:17 – Introduction

00:55 – Dig in: The big data unlock for AI

14:02 – Conversation with Edward Calvesbert

57:58 – Hiking Mount Rainier near Seattle

Guest

Edward Calvesbert: https://www.linkedin.com/in/ecalvesbert/

Hosts

Dave Chapman: https://www.linkedin.com/in/chapmandr/

Esmee van de Giessen: https://www.linkedin.com/in/esmeevandegiessen/

Rob Kernahan: https://www.linkedin.com/in/rob-kernahan/

Production

Marcel van der Burg: https://www.linkedin.com/in/marcel-vd-burg/

Dave Chapman: https://www.linkedin.com/in/chapmandr/

Sound

Ben Corbett: https://www.linkedin.com/in/ben-corbett-3b6a11135/

Louis Corbett: https://www.linkedin.com/in/louis-corbett-087250264/

'Realities Remixed' is an original podcast from Capgemini