In the late 1950s, a tuberculosis drug was repurposed as the world’s first antidepressant. Then the selective serotonin reuptake inhibitor (SSRI) Prozac ushered in a new era of antidepressants. Today SSRIs are some of the most widely prescribed drugs in the country, but gaps still exist in our biological understanding of mental health, the overall efficacy of antidepressants, and predicting serious side effects. In response, some scientists and physicians are turning to different classes of drugs altogether to treat depression.

Transcripts and episode sources at acs.org/chainreaction

The discovery of sex hormones in the 1930s led to the development of female birth control, a widely used class of drugs that reshaped cultural norms surrounding fertility and bodily autonomy. But contraception remains largely the responsibility of women. On today’s episode: the evolution of birth control and the future of male contraception.

Transcripts and episode sources at acs.org/chainreaction

Through a few serendipitous discoveries, antibiotics changed the course of history by turning deadly infections into manageable sicknesses. But it didn’t take long for bacteria to begin outsmarting these wonder drugs. On today’s episode: The fascinating world of antibiotics and the efforts to tackle antibiotic resistance, including using AI to come up with new drugs that will only become more essential.

Transcripts and episode sources at acs.org/chainreaction