Breast cancer treatment is changing at an unprecedented pace.

In Episode 3 of Cancer Unfiltered, Dr. Komal Jhaveri and Dr. Neil Iyengar discuss the latest FDA approvals, landmark clinical trials, and emerging treatment strategies that are reshaping care across HR-positive, HER2-positive, and triple-negative breast cancer. From practice-changing DESTINY data to the expanding role of antibody-drug conjugates, this episode breaks down what the latest evidence means for treatment decisions today.

Topics discussed:

• Six new FDA approvals across all major breast cancer subtypes

• Vepdegestrant and the VERITAC-2 trial for ESR1-mutant HR-positive breast cancer

• DESTINY-Breast11, DESTINY-Breast05, and DESTINY-Breast09: key findings and clinical impact

• The growing role of antibody-drug conjugates (ADCs) in first-line metastatic triple-negative breast cancer

• Treatment sequencing and how new approvals are changing clinical decision-making

• Which HER2-positive patients may benefit most from the DESTINY-Breast09 approach

• Brain metastases, PIK3CA mutations, and selecting therapy for high-risk patients

• Giredestrant and the lidERA trial: improving endocrine therapy options

• VIKTORIA-1 and emerging therapies targeting the PI3K/AKT/mTOR (PAM) pathway

• The future of breast cancer treatment and practice-changing data to watch

Whether you're an oncologist, advanced practice provider, researcher, or healthcare professional, this episode offers practical insights into the rapidly evolving breast cancer treatment landscape and what these developments mean for patient care.

▶️ Watch on YouTube - https://youtu.be/m0l8feuG6Y8

🎧 Listen on Spotify, Apple Podcasts, Amazon Music, CastBox, & iHeartRadio - https://linkin.bio/cancerunfiltered

Cancer Unfiltered is part of the Community Health Media Podcast Network, where meaningful conversations help patients, caregivers, advocates, and healthcare professionals learn from one another, one story at a time.

#CancerUnfiltered #BreastCancer #Oncology #MedicalOncology #FDAApprovals #DESTINYBreast11 #DESTINYBreast05 #Vepdegestrant #TripleNegativeBreastCancer #HER2Positive #CancerPodcast #CommunityHealthMedia

The conversation continues.

In Episode 2 of Cancer Unfiltered, Dr. Komal Jhaveri and Dr. Neil Iyengar break down the biggest updates from ESMO Breast 2026, including DESTINY-Breast11, SERENA-6, ctDNA monitoring, exercise and metabolic health, emerging novel therapies, and the future of ER-positive breast cancer treatment.

From controversial questions surrounding molecular progression to exciting new therapies in development, this episode explores where breast cancer care is heading next.

If Episode 1 introduced the conversation, Episode 2 takes it even further.

▶️ Watch on YouTube - https://youtu.be/Bq6HCsyn7b4

🎧 Listen on Spotify, Apple Podcasts, Amazon Music, CastBox, & iHeartRadio - https://linkin.bio/cancerunfiltered

Cancer Unfiltered is part of the Community Health Media Podcast Network, where meaningful conversations help patients, caregivers, advocates, and healthcare professionals learn from one another, one story at a time.

#CancerUnfiltered #ESMOBreast2026 #BreastCancer #Oncology #MedicalOncology #ERPositive #HER2Positive #ctDNA #SERENA6 #CancerPodcast #HealthcareEducation #CommunityHealthMedia

Before the data drops, the hot takes, and the controversies, there was Miami.

In this special bonus episode, Dr. Komal Jhaveri and Dr. Neil Iyengar introduce Cancer Unfiltered and discuss the biggest questions shaping breast oncology today.

From oral SERDs and overcoming ESR1 mutations to the monotherapy vs. combination debate, ADC sequencing, first-line triple-negative breast cancer strategies, and the real-world application of precision medicine, this conversation lays the foundation for everything that follows.

This is where Cancer Unfiltered began.

▶️ Watch on YouTube - https://youtu.be/sMbRsnGNamQ

🎧 Listen on Spotify, Apple Podcasts, Amazon Music, CastBox, & iHeartRadio - https://linkin.bio/cancerunfiltered

Cancer Unfiltered is part of the Community Health Media Podcast Network, where meaningful conversations help patients, caregivers, advocates, and healthcare professionals learn from one another, one story at a time.

#CancerUnfiltered #BreastCancer #Oncology #MedicalOncology #ESR1 #OralSERD #ADC #TripleNegativeBreastCancer #MetastaticBreastCancer #CancerPodcast #CommunityHealthMedia