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Colorado Buffaloes (2-4) face Oklahoma State (4-2) in a critical Big 12 matchup on October 24. After a 27-24 loss to Utah, the focus is on quarterback Isaac Wilson's turnover issues and offensive line protection.

Key players include Isaac Wilson, JaQuail Smith, and DeAndre Moore Jr. The Buffaloes must address pass protection and rushing consistency to stop their four-game losing streak against a physical Oklahoma State defense.

Analysis covers the impact of Deion Sanders' leadership, Randon Fontenette's defensive presence, and the importance of ball security in this high-stakes road game.

In this episode: Matchup Storylines & Utah Loss Analysis · Key Players & Injury Report · Keys to Victory & Prediction.

More Buffaloes coverage, previews & recaps: https://www.beatlinesports.com/shows/colorado-buffaloes-football/
Full transcript: https://cdn.beatlinesports.com/cfb/colo/2026-10-22/transcript.html

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