Episode 149 -

In this episode of the Bioenergetics Beat Podcast, Heather Gray sits down with Shalin Shah, CEO of Marius Pharmaceuticals, to discuss oral testosterone replacement therapy, the growing crisis of testosterone deficiency in men, and why this hormone has been unfairly stigmatized for decades.

Shalin shares how his own low testosterone and an investment opportunity led him to develop Kyzatrex, an FDA-approved oral testosterone that bypasses the liver through lymphatic absorption. He explains why testosterone levels in men have dropped 50% over five decades, how deficiency is showing up in men as young as their 30s, and why testosterone may be the single most telling biomarker for overall metabolic health.

Throughout the episode, listeners will learn:

• Why testosterone levels are declining in younger and younger men

• How oral testosterone works through lymphatic absorption without liver toxicity

• The difference between injectable, gel, and oral replacement options

• The connection between testosterone, cardiovascular health, and insulin sensitivity

• Why baseline testing and self-advocacy are essential first steps

• How restoring testosterone can create a virtuous cycle for energy, fitness, and focus

About Shalin Shah:

Shalin Shah is the CEO of Marius Pharmaceuticals, widely known as "The Metabolic CEO." Shalin has spent decades immersed in hormone replacement therapy, leading the charge to destigmatize testosterone, a hormone long considered taboo and unfairly miscategorized, when in fact testosterone serves a laundry list of critical functions for both men and women. Shah recently participated in the FDA's expert panel on men's health and testosterone therapy and has been an outspoken advocate for better access to treatment, testing, and education for patients and physicians alike.

Where to find more information and resources:

Kyzatrex: https://kyzatrex.com/

Marius Pharmaceuticals: https://mariuspharma.com/

The Testosterone Project: https://testosteroneproject.com/

Thrive Better: https://thrivebetter.com/testosterone

Instagram: @themetabolicceo

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