Welcome back to "What I'd Tell My Family." In today’s episode, we take a deep dive into one of the least discussed, yet most powerful predictors in neurology: the APOE4 gene and its connection to Alzheimer’s disease. Joined by Dr. Todd Levine, we unravel what it means to carry APOE4, the difference between having one or two copies, and how genetic information can shape the way we approach risk, prevention, and family conversations about memory loss.

We address the big questions: Who should get tested for APOE4? What does a positive or negative result actually mean? How can lifestyle changes and new advances in blood-based biomarkers impact your long-term brain health? And how should families navigate the complex emotions and decisions that come with learning about genetic risk?

Whether Alzheimer’s is part of your family story or you just want to better understand the role of genetics in dementia, this episode provides grounded advice, expert insight, and the candid conversation most clinics skip. Grab a seat at the table; this is information every family should hear.

Timestamps:

00:00 Understanding genes and proteins basics

05:00 Understanding the APOE Protein Function

08:57 Answering the "so what" question

12:02 Discussing Alzheimer's risk and prevention

14:16 Discussing Alzheimer's risk and treatments

20:17 Understanding genetic risk and biomarkers

21:53 Discussing genetic testing decisions

25:16 Discussing APOE and Alzheimer's treatment

27:30 Ending the conversation

Dr. Todd Levine on LinkedIn - https://www.linkedin.com/in/todd-levinemd/

Neuro Concierge - https://neuro-concierge.com/

Podcast - https://what-id-tell-my-family.beam.ly/

What I´d Tell My Family Podcast on LinkedIn - https://www.linkedin.com/company/what-id-tell-my-family/

Podcast Partner - https://www.tophealth.care/

“Disclaimer: Informational only. Not medical advice. Consult your doctor for guidance.”