In our latest episode of The AJP-Heart and Circ Podcast, Associate Editor Dr. Jason Carter (Baylor University) interviews authors Dr. Michael Joyner (Mayo Clinic), Dr. Nathaniel Jenkins (University of Wisconsin-Madison), Dr. Austin Robinson (Indiana University), Dr. Nisha Charkoudian (Environmental Physiologist in the Boston Area), and Dr. Manda Keller-Ross (University of Minnesota) about their recent Guidelines in Cardiovascular Physiology article about rigor and reproducibility of heart rate variability (HRV) within human cardiovascular research. Carter et al. take an evidence-based approach to propose more consistent and rigorous measurement and interpretation of HRV within human cardiovascular research and application. Listen to this engaging conversation about the utility of HRV as a cardiovascular risk stratification tool, but also the challenges of interpreting and contextualizing HRV assessments using wearable technology. Don’t miss this must-listen episode!

Jason R. Carter, Nathaniel D. M. Jenkins, Jeremy A. Bigalke, Austin T. Robinson, Manda L. Keller-Ross, Jody L. Greaney, Ida T. Fonkoue, Paul J. Fadel, Vaughan G. Macefield, Nisha Charkoudian, Benjamin D. Levine, and Michael J. Joyner Guidelines for rigor and reproducibility of heart rate variability within human cardiovascular research Am J Physiol Heart Circ Physiol, published August 28, 2026. DOI: 10.1152/ajpheart.00041.2026

Join us for happy hour! In our new episode of The AJP-Heart and Circ Podcast, Associate Editor Dr. Amanda LeBlanc (University of Louisville) hosts a casual, witty, and engaging conversation with co-authors Dr. Camilla Wenceslau (University of South Carolina), Dr. Pooneh Bagher (University of Nebraska Medical Center), Dr. Brant Isakson (University of Virginia), Dr. Thomas Jepps (University of Copenhagen), and Dr. Aaron Trask (Nationwide Children's Hospital). The topic at hand for this lively group? The latest must-read Guidelines in Cardiovascular Research article by McCarthy et al. on evaluating endothelial function in vascular tissue. Listen now…you’ll laugh a little and learn a lot.

Cameron G. McCarthy, Christian Aalkjær, Pooneh Bagher, Andreas M. Beyer, Ebbe Boedtkjer, Gisele F. Bomfim, Jerome W. Breslin, Ana M. Briones, Jorge A. Castorena-Gonzalez, Tiago J. Costa, Zhiyu Dai, Ana P. Davel, Scott Earley, Julie K. Freed, Christopher Garland, Brant E. Isakson, Thomas A. Jepps, Joanna Kalucka, Boris Lavanderos, Ayako Makino, Charles E. Norton, Steven S. Segal, Wenbin Tan, Aaron J. Trask, Calum Wilson, Scott D. Zawieja, and Camilla F. Wenceslau Guidelines for evaluating endothelial function in vascular tissue Am J Physiol Heart Circ Physiol, published May 1, 2026. DOI: 10.1152/ajpheart.00656.2025

After a heart attack, where do cardiomyocyte-derived small EVs go in the body and how does that change over time? In this episode, Associate Editor Dr. Crystal Ripplinger (UC Davis School of Medicine) interviews author Dr. Jiang Chang (Texas A&M University Health Science Center) and expert Dr. Raj Kishore (Temple University Lewis Katz School of Medicine) about the study by Wang et al. that investigated the role of small extracellular vesicles (EVs) and their production and biodistribution after myocardial infarction. Using a genetically modified mouse model, the authors mapped the spatiotemporal distribution of these cardiac EVs at different time points post-MI. Initially the authors generated data from only one sex, which does not align with AJP-Heart and Circulatory Physiology journal policies on sex as a biological variable. Treating this as an opportunity rather than an obstacle, the authors completed more rigorous experiments using both male and female mice. What key sex differences did Wang et al. uncover in post-MI pathophysiology? Listen and learn more.

Xinjie Wang, Xiao Du, Zhishi Chen, Wei Yu, Zhongjing Wang, Yanping Chen, Daniel Y. Chang, Garrett Jensen, Weijia Luo, and Jiang Chang Dynamics and Biodistribution of Cardiomyocyte-Derived Small Extracellular Vesicles Following Myocardial Infarction: Sex Differences Am J Physiol Heart Circ Physiol, published December 15, 2025. DOI: 10.1152/ajpheart.00835.2025