Anthropic pointed 950 Claude agents at human genetic data and they found an enzyme system
nobody had described. A real lab then confirmed it exists. This week is the "AI does real
science" episode: Claude's record-breaking physics calculation, a language model trained on
DNA, how a biotech picks what to research with AI, Google's search trick that sometimes
builds on the fifth-best idea, and Google's way to put idle AI agents to sleep.

00:00 Intro
00:55 Claude finds a new enzyme system (950 agents)
08:24 Claude's 9-loop physics record
10:53 Genomic language models: AI trained on DNA
17:52 How a biotech uses AI to pick what to research
19:32 Google ERA: tree search that bets on the fifth-best idea
24:17 Google AX: putting idle AI agents to sleep

Top K — the k things in AI that actually mattered, explained properly.

Every week we take the handful of AI stories worth your attention and go one layer deeper
than the headline. Not "a new model dropped" — what changed architecturally, what it costs
to run, and what it means for the code you write on Monday.

Two engineers. No hype, no takes we can't defend, no reading press releases out loud.

Also here: deep dives on how this stuff actually works, build logs, and whatever we're
currently confused about.

For you if you ship software with LLMs and want to stop treating the model as a black box.

New episode every Monday.

Topics: AI for science, AI agents, Claude, Gemini, genomic language models, tree search,
agent infrastructure, ML engineering.

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AI news, machine learning, LLM, Top K, AI podcast, AI engineering, AI agents, Claude,
Anthropic, AI for science, genomic language model, DNA AI, Google ERA, Gemini, AI agent
infrastructure, tree search