6. Following the Carbon: Tracers and Metabolic Maps
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6. Following the Carbon: Tracers and Metabolic Maps
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Heinrich Wieland argues that biological oxidation is a matter of taking hydrogen away rather than adding oxygen, and spends years arguing it with Otto Warburg. Rudolf Schoenheimer feeds animals molecules labelled with heavy isotopes and discovers that the body is not a stable structure being topped up but a thing in constant turnover, its own material continually replaced. Yellapragada SubbaRow works out phosphocreatine and ATP, and goes on to methotrexate. Herman Kalckar ties phosphorylation to respiration.
Season Two of We Are Biochemistry is the people behind the pathways, drawn from The Molecule Hunters, the book written by more than five hundred University of Virginia students.
Pairs with Biochemistrypedia Chapter 15, Metabolism: Basic Concepts and Design - biochemistrypedia.com
The full book, its sources, and the individual student credits are free at deppmannlab.com, where the corrections form also takes audiobook pronunciation fixes.
Narrated by a digital voice.