『57: The Brain’s Immune System: How Metabolism Shapes Cognitive Health with Dr. David Perlmutter』のカバーアート

57: The Brain’s Immune System: How Metabolism Shapes Cognitive Health with Dr. David Perlmutter

57: The Brain’s Immune System: How Metabolism Shapes Cognitive Health with Dr. David Perlmutter

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What if the brain’s future is shaped by more than genetics and age? In this episode of Take Back Your Health®, Dr. Amy Myers reconnects with neurologist and author Dr. David Perlmutter to discuss the brain’s immune system, metabolism, inflammation, and the lifestyle factors that may influence cognitive health. Dr. Perlmutter joins Dr. Amy to discuss his newest book, Brain Defenders, and the role of microglia, the brain’s immune cells. They explore immunometabolism, blood sugar, sleep, exercise, diet, perimenopausal hormone changes, APOE4, and why brain-health work may need to begin long before symptoms appear. What you’ll learn in this episode: How microglia can shift between supportive and more destructive states Why blood sugar, insulin, A1C, inflammation, sleep, and exercise matter for brain health What Dr. Perlmutter discusses about P-tau217, homocysteine, and related markers Why cognitive-health habits may need to begin in the 30s and 40s How estrogen changes during menopause may interact with synapses and microglia Why genetics can influence risk without determining your future The role of diet, movement, mitochondria, hyperbaric oxygen, and social connection About Dr. David Perlmutter Dr. David Perlmutter is a board-certified neurologist and author whose work focuses on brain health, nutrition, metabolic health, and neurodegenerative disorders. His newest book, Brain Defenders, focuses on the brain’s immune cells and their relationship to long-term brain health. Resources and People Mentioned Dr. David Perlmutter’s official website: https://drperlmutter.com/ Brain Defenders official book website: https://braindefenders.com/ Dr. David Perlmutter on Instagram: https://www.instagram.com/davidperlmutter/?hl=en Connect with Dr. Myers Website: https://www.dramymyers.com/ Inner Circle: https://www.drmyersinnercircle.com Newsletter: https://dramymyers.com/ Facebook: https://www.facebook.com/dramymyers Instagram: https://www.instagram.com/dramymyers Connect with Dr. David Perlmutter Website: https://drperlmutter.com/ Instagram: https://www.instagram.com/davidperlmutter/?hl=en 🚨 Special Offer 🚨 Sunlighten is a sponsor of Take Back Your Health®. Visit Sunlighten to learn more about Sunlighten infrared saunas and access Dr. Amy’s $200 savings offer. 🚨 Exclusive Sunlighten Savings 🚨 Dr. Amy Myers has used a Sunlighten sauna for 16 years to support circulation, the body’s natural detox pathways, and relaxation. Discover Sunlighten’s mPulse Intelligent Sauna with PulseIQ™ technology, along with Amplify and the portable Solo System. Visit the Dr. Amy Myers Sunlighten offer page to save up to $2,100 plus free shipping. Use code Dr. Amy Myers. Episode Timestamps 00:00 — Welcome and Dr. Perlmutter’s return 01:03 — From mainstream neurology to root-cause exploration 05:53 — Metabolism, inflammation, and the brain’s immune system 08:04 — Immunometabolism as the missing piece 12:14 — Microglia and their supportive versus destructive states 17:18 — P-tau217, fasting insulin, homocysteine, and A1C 20:43 — Early-life sugar exposure and immune regulation 25:10 — Diet, blood-sugar monitoring, CGMs, fiber, and healthy fats 27:59 — Perimenopause, estrogen, microglia, and brain changes 36:18 — Lifestyle intervention and cognitive outcomes 41:45 — Alzheimer’s as a spectrum and plasma exchange 46:21 — Hyperbaric oxygen, mitochondria, and brain health 51:45 — Modifiable risk factors, genetics, and APOE4 55:59 — Three ways to take back your brain 56:58 — Brain Defenders and where to find Dr. Perlmutter
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