『56. The Overlooked Hormone Behind Fasting Blood Sugar | Glucagon, Cortisol & Mitochondria (Part 3)』のカバーアート

56. The Overlooked Hormone Behind Fasting Blood Sugar | Glucagon, Cortisol & Mitochondria (Part 3)

56. The Overlooked Hormone Behind Fasting Blood Sugar | Glucagon, Cortisol & Mitochondria (Part 3)

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Why is your fasting blood sugar high even when you're eating clean, training consistently, cutting sugar, or even following a low-carb diet? That's what I'm breaking down in Part 3 of this series. I've dealt with this myself. There was a period where I was eating low carb, doing intermittent fasting, training fasted, and still waking up with fasting glucose in the 90s and sometimes higher. At first glance, that doesn't make much sense. But once I started looking deeper into glucagon, cortisol, adrenaline, liver glucose production, and what happens when your cells aren't producing enough ATP, the picture changed. Your fasting blood sugar isn't just about what you ate the night before. Your liver is making glucose all night long, and hormones like glucagon, cortisol, and adrenaline help control how much gets released into the bloodstream. In this episode, I break down: Why low ATP can create a stress responseHow adrenaline raises blood sugar and free fatty acidsHow cortisol can keep gluconeogenesis runningWhy glucagon may be one of the most overlooked hormones in metabolic healthHow insulin and glucagon are supposed to regulate each otherWhy fasting glucose can stay elevated even on a low-carb dietHow the Randle cycle can interfere with glucose oxidationWhy simply cutting more carbs may lower the number without fixing the underlying issueThe labs I look at beyond fasting glucose alone This connects directly back to Parts 1 and 2, where I explained how mitochondrial dysfunction can reduce ATP production even when enough calories are coming in. When that energy deficit keeps happening, your body responds like there's an emergency. And over time, that hormonal response can start showing up in your labs. If you haven't watched the first two episodes yet, go back and start there. It'll make this one much easier to follow. In Part 4, I'm going to zoom out and show how this same underlying metabolic dysfunction can show up as several different problems across the body. Subscribe and turn on notifications so you don't miss it. Stay Healthy AF, Zane Episode Timestamps: 0:00 The Overlooked Hormone Behind Fasting Blood Sugar0:45 Zane's Own Experience With Elevated Fasting Glucose2:00 When You're "Doing Everything Right" But Glucose Is Still High3:00 How Seed Oils & Mitochondrial Dysfunction Fit Into the Story5:00 Adrenaline: The First Stress Response6:20 How Adrenaline Raises Fat & Glucose in the Blood8:00 Why Stored Linoleic Acid Matters8:45 Cortisol Takes Over When the Stress Doesn't Stop10:00 Gluconeogenesis & Chronically Elevated Cortisol12:00 Cortisol, PGC-1α & Mitochondrial Repair13:00 Glucagon: The Overlooked Hormone14:00 Why Low ATP Can Drive Glucagon Higher15:00 When Insulin & Glucagon Stop Regulating Each Other16:00 Why Your Liver Makes Glucose Overnight17:30 The Randle Cycle Explained19:00 Why Glucose Can Back Up in the Bloodstream20:00 Why Cutting More Carbs May Not Fix the Problem21:00 What Your Fasting Glucose Number Doesn't Tell You21:40 Labs Zane Looks At22:40 What's Coming in Part 423:20 Looking at the Whole Metabolic Pattern Connect with Zane Griggs: 📲 Instagram: @zanegriggsfitness 🌐 Website: zanegriggs.com Research Referenced in This Series Hulbert et al. (2007) — Membrane Composition & Lifespan — https://pubmed.ncbi.nlm.nih.gov/17928583/ Seebacher et al. (2010) — Oxidative Metabolism & Proton Leak — https://pubmed.ncbi.nlm.nih.gov/20586603/ Paradies et al. (2009) — Cardiolipin & Mitochondrial Dysfunction — https://pubmed.ncbi.nlm.nih.gov/19368971/ Chicco & Sparagna (2007) — Cardiolipin Alterations — https://pubmed.ncbi.nlm.nih.gov/16899548/ Stanley et al. (2012) — Dietary Fat & Mitochondrial Function — https://pmc.ncbi.nlm.nih.gov/articles/PMC4067133/ Khairallah et al. (2012) — Membrane Fatty Acids & Mitochondrial Function — https://pmc.ncbi.nlm.nih.gov/articles/PMC3316678/ Penzo et al. (2002) — Fatty Acids & Mitochondria — https://pubmed.ncbi.nlm.nih.gov/12206909/ Hulbert et al. (2006) — Peroxidation-Resistant Membranes & Longevity — https://pubmed.ncbi.nlm.nih.gov/16620917/ Pamplona et al. (2004) — Fatty Acids & Mitochondrial DNA Damage — https://pubmed.ncbi.nlm.nih.gov/15130667/ Porter, Hulbert & Brand (1996) — Mitochondrial Proton Leak — https://pubmed.ncbi.nlm.nih.gov/8997352/
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