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The San Francisco 49ers (4-0) prepare for a critical Week 5 road matchup against the Seattle Seahawks. With Nick Bosa ruled out, Matthew Judon must lead the pass rush as Mykel Williams makes his season debut. Brock Purdy’s efficiency and Christian McCaffrey’s ground game will be tested against a physical Seattle defense.

Key players discussed include Brock Purdy, Christian McCaffrey, Matthew Judon, Mykel Williams, George Kittle, and Phil Evans. We analyze the impact of injuries to Pat Surtain II and Riley Moss, and how the 49ers’ offensive line can protect Purdy against Seattle’s aggressive front seven.

Topics covered include the defensive adjustment without Nick Bosa, the strategic importance of Dre Greenlaw’s tackling, and predictions for a tight 20-17 victory for San Francisco.

In this episode: Matchup Analysis and Injury Impact · Key Players and Defensive Line Depth · Keys to Victory and Final Prediction.

More 49ers coverage, previews & recaps: https://www.beatlinesports.com/shows/san-francisco-49ers/
Full transcript: https://cdn.beatlinesports.com/nfl/sf/2026-10-10/transcript.html

49ers vs seahawks preview, mykel williams return acl, nick bosa injury update, matthew judon pass rush, brock purdy stats 2026, christian mccaffrey rushing, george kittle targets, phil evans receptions, dre greenlaw tackles, seahawks defense strength, nfc west standings 2026, kyle shanahan wins

#49ers #Seahawks #NFL #BrockPurdy #ChristianMcCaffrey #MykelWilliams #MatthewJudon #NFCWest #SundayFootball #BeatlinePodcast #49ersNation #SeahawksNation #NFLPreview #Week5