The San Francisco 49ers are heading to Melbourne, Australia for a huge Week 1 matchup against the Los Angeles Rams! We preview the game and break down how the 49ers can win, how they could lose and the biggest keys to victory.

Can Nick Bosa and the 49ers defense slow down Matthew Stafford? Will San Francisco's run defense hold up? Can Brock Purdy survive the Rams' pass rush? Is Christian McCaffrey the X-factor? And how much will George Kittle impact the game?

Plus, we dive into the biggest wildcard: the international travel plans. The 49ers arrived in Australia a week early, while the Rams are arriving just one day before kickoff. Does that give San Francisco an advantage? The Rams are 3-0 in international games and have outscored opponents 92-17.

We also preview Mike Evans' 49ers debut and the expected debuts of Carver Willis and De'Zhaun Stribling.

49ers vs. Rams. Week 1. Australia. Who wins?

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