The San Francisco 49ers are 2-0 and coming off commanding wins over the Los Angeles Rams and Miami Dolphins. Now, Kyle Shanahan and the 49ers return home for a Week 3 matchup against the Arizona Cardinals.

Arizona enters the game at 1-1 after an impressive-looking Week 1 against the Chargers before falling apart against the Seattle Seahawks in Week 2. But history tells us not to overlook the Cardinals — Arizona has consistently given the 49ers problems throughout the Kyle Shanahan era.

Can Brock Purdy and the 49ers offense keep rolling toward 3-0, or will the Cardinals once again be a thorn in San Francisco's side?

On this episode of 49ers Access, we break down the biggest storylines and matchups heading into 49ers vs. Cardinals:

• Brock Purdy vs. the Arizona Cardinals secondary
• Why Purdy could have a huge game against Arizona
• Mike Evans vs. the Cardinals' perimeter coverage
• Deebo Samuel's potential impact underneath
• George Kittle vs. Arizona's linebackers
• Christian McCaffrey vs. a Cardinals run defense that has been strong by EPA
• The 49ers offensive line vs. Arizona's front seven
• Can Arizona's rushing attack exploit San Francisco's banged-up defensive line?
• The importance of Osa Odighizuwa and Gracen Halton
• Jacoby Brissett's history against the 49ers
• How San Francisco should defend Trey McBride
• Marvin Harrison Jr. and Michael Wilson
• Why the Cardinals could make this game interesting
• Nick Bosa's Week 3 revenge opportunity
• A bold prediction for Nick Bosa against Arizona

And yes... THERE'S GOING TO BE A LOT OF JUICE CELEBRATIONS THIS SUNDAY!

Can the 49ers start the season 3-0?

Listen to 49ers Access for San Francisco 49ers news, analysis, game previews, reactions, NFL coverage and everything surrounding the 49ers.

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