The San Francisco 49ers held their final practice Wednesday in Santa Clara ahead of their international flight that evening to Melbourne, Australia. For the first time all offseason, star defensive end Nick Bosa and tight end George Kittle were present and fully participating together. On "49ers Talk," Matt Maiocco and Jennifer Lee Chan discuss how the pair of veteran superstars can navigate the long journey down under with a clean bill of health. Later, quarterback Brock Purdy opens up to Matt about his maturation as a leader, a family-man, and his excitement for the upcoming season.

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(0:00) Last 49ers practice in Santa Clara before departing for Australia
(2:00) Nick Bosa and George Kittle return to full practice
(6:00) Keys to adjusting to the time change: a custom flight plan for every player
(10:00) 49ers current health situation
(20:00) Brock Purdy exclusive 1-on-1 interview
(36:00) Breaking down Brock Purdy's NFL impact since being drafted as Mr. Irrelevant

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It's roster cutdown day, and the San Francisco 49ers had to make some tough decisions as they whittled their squad down from 90 to 53 players. On this episode of "49ers Talk," Matt Maiocco and Jennifer Lee Chan provide in-depth analysis of the 49ers' initial 53-man roster and what these decisions mean for the upcoming season.
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(0:00) Initial 53-man roster takeaways
(5:00) Injured/Reserve candidates
(15:00) Breaking down offensive roster construction
(25:00) Breaking down defensive roster construction
(35:00) Big-picture roster discussion

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The 49ers wrapped up their preseason with a 18-12 touchdown-less win over the Las Vegas Raiders Thursday at Allegiant Stadium. Next up is the difficult task of finalizing the 53-man roster by Sunday afternoon. On "49ers Talk,' Matt Maiocco and Jennifer Lee Chan discuss which position-group competitions remain and any late risers who could challenge for a roster spot with injuries undoubtedly playing a major role in final decisions.
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(2:00) Kyle Shanahan/John Lynch have big roster decisions ahead
(6:00) Biggest camp competition remains at left guard
(9:00) With Dominick Puni still in concussion protocol will he even travel to Australia?
(17:00) The race to be CMC’s backup is wide-open between Kaelon Black, Jordan James
(37:00) Welcome Kylen Mills as the new host of 49ers Pre/Postgame shows on NBC Sports Bay Area

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