Two desperate journeys across the American West. One a high-stakes manhunt, the other a father's fierce fight for his son. Both are on a collision course with death.

When a charismatic Native rights activist is accused of murder, he flees into the wilderness—and takes wildlife ranger Loq’s sister with him. Risking his badge and his life, Loq launches a frantic pursuit across the rugged terrains of Oregon, Idaho, and Montana, tracking a path forged a century earlier during a legendary, bloody flight for freedom. Teaming up with a determined tribal police officer, Loq must navigate a treacherous landscape of desire, deception, and a rising body count. Together, the pair must outrun a ruthless federal agent and pull his sister from the brink before the trail ends in a slaughter.

Meanwhile, Nick Drake faces an entirely different kind of heartbreak.

Back in the High Lonesome, Nick's adopted son is still violently haunted by the trauma of war-torn Vietnam, while a devastating cancer diagnosis strikes at the heart of their family. Desperate for healing and meaning, father and son journey deep into the wilderness on a quest for peace. But the desert offers no sanctuary. When deadly, unseen forces target them in the wild, their spiritual retreat instantly morphs into a brutal, raw fight for survival.

Rich in atmospheric dread and deeply moving emotion, this award-winning installment pushes the bonds of blood, brotherhood, and family to their absolute breaking point.