Lamentations is a novel about the first group of families crossing west to Oregon in 1842, from the perspective of the dozen women on the trip. Although none of these women left a written record of her journey, the company clerk's daily notations provided documentation of historical events. Based on these records and the author's own decades of work as a historian, Carol Kammen provides an interpretation of the women's thoughts and feelings as events played out in and around the wagons heading west.

In this novel the men are in the background - and we hear the women ponder the land, their right to be passing through, their lives and how they are changing, the other people in the company, the Native Americans they encounter, and their changing roles. Lamentations is about women's reality as wives or unmarried sojourners, as literate or illiterate observers, and as explorers of the land.

Kammen gives voice to these women as they consider a strange new land and the people who inhabit it, mulling over what they, as women of their time, could not say aloud. They face the difficulties of the road, the slow trust that builds between some of them, and the oddities of the men with whom they travel. These women move from silent witnesses within a constrained gender sphere to articulate observers of a complicated world they ultimately helped to shape.