Two girls and three boys, all with strikingly different looks and talents, meet at the Atwood school as young children. Together, they become an inseparable group - known to outsiders as "The Big Five" - and lean on one another through all the bumps and bends of childhood and adolescence. But when the tight-knit group graduates and scatters to different colleges, their lives diverge dramatically, and some of the friends are lost forever....

A chubby little girl with blond hair, blue eyes, and ordinary looks, Victoria Dawson has always felt out of place in her family, especially in body conscious Los Angeles. Her parents are disappointed by their daughter’s looks. Later in life, the one thing Victoria knows is that she has to get as far away from home as possible and, after college in Chicago (which her parents disapprove of), she moves to New York City.

Nicole “Coco” Martin's destined to have it all. As the only child of doting, successful parents, she's been given every opportunity in life. Having inherited her mother’s stunning beauty and creativity, along with her father’s work ethic and diligence, she has the world at her feet. Her graduation from Columbia's fast approaching, and with it the summer job of her dreams working at a magazine. Between work, leisurely weekends at her family’s home in Southampton, and spending as much time as possible with her best friend, Sam, life couldn’t be better - until tragedy strikes.

Isabel Gibson has all but perfected the art of forgetting. She’s a New Yorker now, with nothing left to tie her to Brinkley’s Island, Maine. Her parents are gone, the family bookstore is all but bankrupt, and her sister, Sophie, will probably never speak to her again. But when a mysterious letter arrives in her mailbox, Isabel feels herself drawn to the past. After years of fighting for her independence, she dreads the thought of going back to the island.

Lucas knows the perfect night entails just three things: video games, wine, and pad thai. Peanuts are a must! Other people? Not so much. Why complicate things when he’s happy alone? Then one day the apartment board, a vexing trio of authority, rings his doorbell. And Lucas’s solitude takes a startling hike. They demand to see his frying pan. Someone left one next to the recycling room overnight, and instead of removing the errant object, as Lucas suggests, they insist on finding the guilty party. But their plan backfires. Colossally.