L.M. Montgomery's novel introduces the world to the lovable and energetic Anne, who at the beginning of the audiobook is adopted by the Cuthbert siblings, Matthew and Marilla. The brother and sister realize that they are getting up in their years, and intend to adopt a young boy to help Matthew maintain the property. Through a mix up, however, they get Anne instead. Rather than sending her back to the orphanage, the siblings decide to keep her, and though she makes a few mistakes at the start of her stay, they come to realize how invaluable she is to their lives.

Anne, who is 11 at the time of her adoption, has never had much training in the way of social graces. There are quite a few events that take place in which the Cuthbert siblings hide their head in shame over something that Anne has said or done, but after Anne saves the life of a young girl who is very sick, the entire town comes to love her for who she really is.

Eventually, Anne grows into a mature teen and spends the majority of her time devoting herself to academics, which pays off when she is awarded a scholarship to a prestigious four-year college. A series of unfortunate events, however, force her to rethink her future plans; but Anne does not distress. Instead, she makes the most of her situation and displays a positive attitude about it all.