100: How to Live 100 Healthy Years is YOU: THE OWNERS MANUAL updated for a new generation of readers – a comprehensive, whole-body guide to longevity that uses the latest in medical technology to allow you to personalize your medical treatment and take ownership of your health in ways that were never possible … until now.

Dr. Mark Hyman talks with patients and followers every day who want his advice on what to eat, how to sleep, how to move, and what their labs should show. Their goal: I want to live to 100. Tell me what to do so I stay healthy forever.

But as Hyman explains, it’s not that simple. We don’t live in lab reports or perfectly controlled environments. Instead, we live in unique loops of sleep, food, stress, movement, and emotion that differ from person to person. The good news: there’s more information available about your unique health profile than ever before – data about your specific nutrition requirements, supplementation needs, ideal biomarkers, and best exercise options. And real-time breakthroughs in interpreting and analyzing this information allow us to personalize our treatment plans in powerful new ways. We just need access to that cutting-edge information, and knowledge about how to put it into action.

That’s what 100 is: not just an operating manual, but an optimization manual for the human body. Hyman breaks the book down into 4 parts:

Part I: Why We’re Sick shows us why conventional medicine fails chronic disease and offers a new way of thinking about health rooted in systems rather than symptoms.

Part II: Know Your Body explains the foundations of wellbeing -- nutrition, sleep, exercise, stress, environment, supplements – and how they each contribute to a balanced and enduring health.

Part III: Know Your Numbers shows how to make the most of your individual health data through understanding your unique biomarkers, wearable technology, imaging, and comprehensive testing -- and how technology can help you put that information to use in powerful new ways.

Part IV: Living 100 Health Years put it all together, covering every major body system -- nutrition, metabolic, cardiovascular, brain, gut, immune, energy, toxins, hormones, mental health, and meaning – identifying for each one:

• What can go wrong (early signals and common symptoms)
• What the labs show (biological data we can track)
• What we miss (myths, blind spots, and cultural noise)
• What we can do (simple, non-dogmatic suggestions to begin recalibration and get the body back in balance)

The goal? To help readers reconnect with their biology—not through shame or perfectionism, but through self-awareness, curiosity, and empowered noticing. Once we understand what “healthy” looks like, we can begin set up our live to attain it. And yes, use that information to extend our lifespan. Living to 100 years is, truly, within our grasp.