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This is a book of miracles - medical events witnessed by leading physicians for which there is no reasonable medical explanation, or, if there is, the explanation itself is extraordinary. These dramatic first-person essays detail spectacular serendipities, impossible cures, breathtaking resuscitations, extraordinary awakenings, and recovery from unimaginable disasters. Miracles We Have Seen is a book of inspiration and optimism, and a compelling glimpse into the lives of physicians.

Today, astonishing surgical breakthroughs are making limb transplants, face transplants, and a host of other previously undreamed-of operations possible. But getting here has not been a simple story of medical progress. In Blood and Guts, veteran science writer Richard Hollingham weaves a compelling narrative from the key moments in surgical history. We have a ringside seat in the operating theater of University College Hospital in London as world-renowned Victorian surgeon Robert Liston performs a remarkable amputation in 30 seconds - from first cut to final stitch.

After his father died, James L. Nolan, Jr., took possession of a box of private family materials. To his surprise, the small secret archive contained a treasure trove of information about his grandfather's role as a doctor in the Manhattan Project. Dr. Nolan, it turned out, had been a significant figure.

Nearly two decades after it closed, the South Carolina State Hospital continues to hold a palpable mystique in Columbia and throughout the state. Founded in 1821 as the South Carolina Lunatic Asylum, it housed, fed, and treated thousands of patients incapable of surviving on their own. The patient population in 1961 eclipsed 6,600, well above its listed capacity of 4,823. By the mid-1990s, the patient population had fallen under 700, and the hospital had become a symbol of captivity, horror, and chaos.

Ignác Semmelweis is remembered for the now-commonplace notion that doctors must wash their hands before examining patients. In mid-19th century Vienna, however, this was a subversive idea. With deaths from childbed fever exploding, Semmelweis discovered that doctors themselves were spreading the disease. While his simple reforms worked immediately - childbed fever in Vienna all but disappeared - they brought down upon Semmelweis the wrath of the establishment, and led to his tragic end.

Between the years 1918 and 1920, influenza raged around the globe in the worst pandemic in recorded history, killing at least 50 million people, more than half a million of them Americans. Yet despite the devastation, this catastrophic event seems but a forgotten moment in our nation's past. American Pandemic offers a much-needed corrective to the silence surrounding the influenza outbreak.

Still Not Safe is the story of the rise of the patient - safety movement - and how an "epidemic" of medical errors was derived from a reality that didn't support such a characterization. Physician Robert Wears and organizational theorist Kathleen Sutcliffe trace the origins of patient safety to the emergence of market trends that challenged the place of doctors in the larger medical ecosystem.

He has been called the greatest surgeon of the 20th century. The son of Lebanese immigrants, Michael DeBakey rose from humble beginnings in a backwater Louisiana town to dominate the landscape of modern medicine. His contributions to our understanding and treatment of cardiovascular disease, in particular, were innumerable and epoch-making. DeBakey led a life of high drama, from the streets of Jazz Age New Orleans and the operating theaters of pre-war Europe, to the battlefields of World War II and the floodwaters of Hurricane Katrina.

John C. Kendrew (1917-1997) was a pioneer in structural biology and a catalyst for the emergence of molecular biology in the second half of the 20th century. He was the first person to determine the three-dimensional structure of a protein at atomic resolution and, for this, was awarded the Nobel Prize in Chemistry in 1962. Kendrew ultimately became an international organizer, administrator, and advocate for science, and his expansive legacy lives on today.

Picking up where Berton Roueche's The Medical Detectives left off, The Deadly Dinner Party presents 15 edge-of-your-seat, real-life medical detective stories written by a practicing physician. Award-winning author Jonathan Edlow, MD, shows the doctor as detective and the epidemiologist as elite sleuth in stories that are as gripping as the best thrillers.

In World War II, 59,000 women voluntarily risked their lives for their country as US Army nurses. For more than half a century these women's experiences remained untold, almost without reference in books, historical societies, or military archives. After years of research and hundreds of hours of interviews, Evelyn M. Monahan and Rosemary Neidel-Greenlee have created a dramatic narrative that at last brings to light the critical role that women played throughout the war.

By investigating thousands of descriptions of epidemics reaching back before the fifth-century-BCE Plague of Athens to the distrust and violence that erupted with Ebola in 2014, Epidemics challenges a dominant hypothesis in the study of epidemics, that invariably across time and space, epidemics provoked hatred, blaming of the "other", and victimizing bearers of epidemic diseases, particularly when diseases were mysterious, without known cures or preventive measures.

Government, industry, and the medical profession, however, have a mixed record when it comes to framing policies and generating knowledge to address drug use and misuse. In Strange Trips, Lucas Richert investigates the myths, meanings, and boundaries of recreational drugs, palliative care drugs, and pharmaceuticals as well as struggles over product innovation, consumer protection, and freedom of choice in the medical marketplace.

In Medical Bondage, Cooper Owens examines a wide range of scientific literature and less formal communications in which gynecologists created and disseminated medical fictions about their patients, such as their belief that black enslaved women could withstand pain better than white "ladies". Even as they were advancing medicine, these doctors were legitimizing, for decades to come, groundless theories related to whiteness and blackness, men and women, and the inferiority of other races or nationalities.

Rabies enjoys a fearsome and lurid reputation. Throughout the decades of spiraling growth that defined New York City from the 1840s to the 1910s, the bone-chilling cry of "Mad dog!" possessed the power to upend the ordinary routines and rhythms of urban life. In Mad Dogs and Other New Yorkers, Jessica Wang examines the history of this rare but dreaded affliction during a time of rapid urbanization.

The Right to Pain Relief and Other Deep Roots of the Opioid Epidemic offers a new lens through which to view the opioid epidemic as a consequence of serious misunderstandings of both opioids and pain. Based on their extensive research and experience with chronic pain care, science, ethics, and policy, the authors look beyond the usual villains—pharmaceutical companies and pharmacotherapy distributors—to examine the ethical and scientific concepts about pain that made the opioid epidemic possible.

Habitual drug use in the United States is at least as old as the nation itself. Habit Forming traces the history of unregulated drug use and dependency before 1914, when the Harrison Narcotic Tax Act limited sales of opiates and cocaine under US law. Many Americans used opiates and other drugs medically and became addicted. Some tried Hasheesh Candy, injected morphine, or visited opium dens, but neither use nor addiction was linked to crime, due to the dearth of restrictive laws. After the Civil War, American presses published extensively about domestic addiction.

Psychedelic drugs are making a comeback. In the mid-20th century, scientists actively studied the potential of drugs like LSD and psilocybin for treating mental health problems. After a decades-long hiatus, researchers are once again testing how effective these drugs are in relieving symptoms for a wide variety of psychiatric conditions, from depression and obsessive-compulsive disorder to posttraumatic stress disorder and substance addiction.

The stomach is notoriously outspoken. It growls, gurgles, and grumbles while other organs remain silent. For centuries humans have puzzled over this rowdy organ, deliberating on the extent of its influence over cognition, mental wellbeing, and emotions, and wondering how the gut became so central to our sense of self. Traveling from ancient Greece to Victorian England, eighteenth-century France to modern America, historian Elsa Richardson leads us on a tour of the gut, exploring all the ways that we have imagined, theorized, and probed the mysteries of the gastroenterological system.

Beginning with the origins of the concept of mania—and the term maniac—in ancient Greek and Roman civilizations, renowned psychiatrist David Healy examines how concepts of mental afflictions evolved as scientific breakthroughs established connections between brain function and mental illness. Healy recounts the changing definitions of mania through the centuries, explores the effects of new terminology and growing public awareness of the disease on culture and society, and examines the rise of psychotropic treatments and pharmacological marketing over the past four decades.