検索キーワード： 制作 "Tantor Audio" 薬理学

The search to find medicines is as old as disease, which is to say as old as the human race. Through serendipity - by chewing, brewing, and snorting - some Neolithic souls discovered opium, alcohol, snakeroot, juniper, frankincense, and other helpful substances. Ötzi the Iceman, the 5,000-year-old hunter frozen in the Italian Alps, was found to have whipworms in his intestines and Bronze Age medicine, a worm-killing birch fungus, knotted to his leggings.

Big Pharma is more interested in profit than health. This was made clear as governments rushed to produce vaccines during the Covid pandemic. Behind the much-trumpeted scientific breakthroughs, major companies found new ways of gouging billions from governments in the West while abandoning the Global South. But this is only the latest episode in a long history of financializing medicine—from Purdue's rapacious marketing of highly addictive OxyContin through Martin Shkreli's hiking the price of a lifesaving drug to the 4.5 million South Africans needlessly deprived of HIV/AIDS medication.

Join journalist Barry Werth as he pulls back the curtain on Vertex, a start-up pharmaceutical company, and witness firsthand the intense drama being played out in the pioneering and hugely profitable field of drug research. Founded by Joshua Boger, a dynamic Harvard- and Merck-trained scientific whiz kid, Vertex is dedicated to designing - atom by atom - both a new life-saving immunosuppressant drug and a drug to combat the virus that causes AIDS.

The 20th century saw a remarkable upsurge of research on drugs, with major advances in the treatment of bacterial and viral infections, heart disease, stomach ulcers, cancer, and metal illnesses. These, along with the introduction of the oral contraceptive, have altered all of our lives. There has also been an increase in the recreational use and abuse of drugs in the Western world. This Very Short Introduction, in its second edition, gives a nontechnical account of how drugs work in the body.

Promising treatments now in more than 35,000 clinical trials could have dramatic impacts on cancer, autoimmune diseases, organ replacement, heart disease, and even aging itself. These treatments, which are saving the lives of patients in the trials, will soon be rolled to the medical community at large. The key to these breakthroughs is the use of living cells as medicine instead of traditional drugs. Research has found that our bodies are virtual treasure troves of adult cells that act as agents of remarkable healing and repair.

Each day we are exposed to a myriad of natural and human-made chemicals in our food, drinking water, air, soil, at home or at the workplace-pesticide residues, food additives, drugs, household products-but how can we gauge the human health risk posed by these chemicals? Should we believe the somber headlines that depict a serious threat for humans and the environment, or should we follow the reassuring voices of others who claim that the angst is totally unfounded?

One hundred years after a milestone medical discovery, Insulin: The Crooked Timber tells the story of how insulin was transformed from what one clinician called "thick brown muck" into the very first drug to be produced using genetic engineering, one which would earn the founders of the US biotech company Genentech a small fortune. Taking the listener on a fascinating journey, starting with the discovery of insulin in the 1920s through to the present day, the book reveals a story of monstrous egos, toxic career rivalries, and a few unsung heroes.

Since the mid-1950s, the psychoactive compound DMT has attracted the attention of experimentalists, prohibitionists, scientists, artists, alchemists, and hyperspace emissaries. Mystery School in Hyperspace is the first book to delve into the history of this substance, the discovery of its properties, and the impact it has had on poets, artists, and musicians.

The explosion of Internet commerce, coupled with globalization and increased pharmaceutical use, has led to an unprecedented vulnerability in the US drug supply. Today, an estimated 80 percent of our drugs are manufactured overseas, mostly in India and China. Every link along this supply chain offers an opportunity for counterfeiters, and increasingly, they are breaking in. Even when the US system works, consumers are increasingly circumventing the safeguards. Skyrocketing health care costs in the US have forced more Americans to become "medical tourists" seeking drugs, life-saving treatments, and transplants abroad, sometimes in countries with rampant counterfeit drug problems and no FDA. Bitter Pills will heighten the public's awareness about counterfeit drugs, critically examine possible solutions, and help people protect themselves.

Three out of four people addicted to heroin probably started on a prescription opioid, according to the director of the Centers for Disease Control and Prevention. In the United States alone, 16,000 people die each year as a result of prescription opioid overdose. But perhaps the most frightening aspect of the prescription drug epidemic is that it's built on well-meaning doctors treating patients with real problems.

Antibiotics: What Everyone Needs to Know examines the personal and societal implications of our planet's most important - and frequently misused - medications. Grounded in the latest scientific research and crafted for general listeners, Antibiotics: What Everyone Needs to Know offers a clear-eyed overview of where we are, and what the future holds, as antibiotics lose their power.

Bradwel reminds us that the centenary of this apparent "wonder drug" should be no cause for celebration. Insulin often remains inaccessible to those who need it most: elusive prescriptions, uneven availability and sky-high prices result in rationing and desperate do-it-yourself research and development. In the face of bootstraps rhetoric and "Pharma Bro" capitalists, patients across the world are left to fend for themselves. There is a long way to go in the twenty-first century until insulin truly fulfills the extraordinary promises made by its discovery.