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In Monte Guano, a ridiculously small and penniless principality in Renaissance Italy, Prince Ludovico II finds his rule constantly undermined by those around him: his shrewd wife, his official mistress and his three disappointing—if not outright humiliating—sons. As well as having to manage the ever-increasing tributes demanded by the Pope, Prince Ludovico must also contend with feeble conscripts in search of war booty, getting on the pilgrim map, fake currency, religious battles and worst of all, English tourists. 

When impoverished watchmaker Caron invents a pioneering device that could revolutionise timekeeping, his fortunes begin to change. Marrying a young, upper-class widow, he takes on a new noble name - de Beaumarchais - and sets out to conquer Louis XV's court. But his attempts to rise through the ranks of Versailles society are blocked by royal clockmaker Lepaute - as well as courtly crushes, rumours of war and illicit printing.

Florence, 1415. Banker Cosimo Medici is looked down upon as a jumped up money-changer. Then he marries the noble Contessina de Bardi and becomes the richest man in Europe. But his wealth and power threaten the Florentine elite, who are determined to bring him down. However, the House of Medici cannot be crushed that easily. Sixty years and many violent deaths later, the family are the unquestioned, ruthless rulers of Florence.