Episode 4 Dr. David LeMay

"Bridging Resolution Biology and Real-World Clinical Practice: SPMs in Elite Performance, Sports Medicine & Recovery"

Welcome to the SPM Podcast, the podcast about Specialized Pro-Resolving Mediators. Subscribe, leave a comment, and share this episode with anyone passionate about cutting-edge science and better health outcomes.

Episode Summary:

In this powerful episode, we are honored to welcome the leading specialist bridging innovative resolution biology with real-world clinical practice: Dr. David LeMay.

Dr. LeMay shares his extensive experience translating the science of Specialized Pro-resolving Mediators (SPMs) into practical protocols used with professional athletes, special operations forces, and high-performing individuals.

He explains how SPMs actively resolve inflammation, accelerate recovery from injury and concussion, reduce reliance on NSAIDs, and support long-term performance and metabolic health.

Through compelling stories from NBA, NFL, NHL, and MLB organizations,

Dr. LeMay demonstrates why shifting from simply blocking inflammation to actively promoting its resolution represents a major paradigm shift in sports medicine and clinical practice.

Guest Bio:

Dr. David LeMay is a board-certified physician in Physical Medicine and Rehabilitation, with additional certification in Metabolic and Nutrition Medicine and advanced training in anti-aging and regenerative medicine.

He is the founder of Regenesis Lifestyle Performance Medicine in Pensacola, Florida, where he focuses on performance optimization, inflammation resolution, and helping patients return to peak function.

Dr. LeMay earned his medical degree from the University of Nevada School of Medicine in 1996, followed by a residency in Physical Medicine and Rehabilitation at the University of Texas Health Science Center at San Antonio.

He has served as a performance medicine consultant for multiple NBA, NFL, NHL, and MLB organizations and has worked extensively with special operations forces, veterans, and high-performing individuals.

He has also served as associate clinical faculty at Florida State University College of Medicine and as a visiting research scientist at the Institute for Human and Machine Cognition (IHMC).

Key Topics Covered:

Dr. LeMay’s journey into medicine, sports injuries, and performance optimization. What Specialized Pro-Resolving Mediators (SPMs) are and why they matter.

The lipid mediator class switch — moving from inflammation to active resolution.

Clinical success using SPMs with professional athletes and military personnel The risks of overusing NSAIDs and how they can delay healing.

Real-world application of SPM supplements in elite performance and recovery.

The future of resolution pharmacology in sports medicine and clinical practice.

Resources Mentioned:

Atletico Madrid Sports Medicine Conference Lecture by Dr. David LeMay

https://youtu.be/Tl86NSfLeyM?is=dz3iRGj1j0mIPgkQ

Podcast Episode 69: David LeMay – Countering Inflammation with SPMs

https://www.ihmc.us/stemtalk/episode-69/

Episode 170: Charles Serhan on Specialized Pro-Resolving Mediators (hosted by Dr. David LeMay & Ken Ford)

https://www.ihmc.us/stemtalk/episode-170/

Regenesis Lifestyle Performance Medicine – Pensacola, FL https://www.regenesisperformance.com/providers

Episode 5 Dr. Ganesh V. Halade

"A Journey Through Resolution Biology: SPMs in Cardiac Repair, Diet, and Chronic Inflammation"

Welcome to the SPM Podcast, the podcast about Specialized Pro-Resolving Mediators. Subscribe, leave a comment, and share this episode with anyone interested in inflammation resolution, heart health, and cutting-edge resolution science.

Episode Summary:

In this insightful episode, we welcome Dr. Ganesh V. Halade, a leading cardiovascular scientist and expert in inflammation-resolution biology. Dr. Halade shares his remarkable journey from growing up in a farming family in India surrounded by nature and curious about healing to becoming a tenured professor whose research is reshaping our understanding of how the body actively turns off inflammation.

He explains Specialized Pro-Resolving Mediators (SPMs) and details how these endogenous lipid mediators (derived from omega-3 and omega-6 fatty acids) orchestrate the safe resolution of inflammation, promote tissue repair, and prevent progression to chronic diseases like heart failure.

Guest Bio:

Dr. Ganesh V. Halade, PhD, is a tenured Professor in the Division of Cardiovascular Sciences at the University of South Florida’s (USF) Morsani College of Medicine and Heart Institute in Tampa, Florida.

Originally from India, he earned his PhD in Pharmacology from the University of Mumbai. He completed postdoctoral training at the University of Texas Health Science Center at San Antonio with mentors Gabriel Fernandes and Merry Lindsey before advancing his career at the University of Alabama at Birmingham and now at USF.

His lab focuses on Specialized Pro-Resolving Mediators (SPMs), the spleen-heart connection, lipidomics, cardiac repair after heart attacks, heart failure (including HFpEF), and the links between diet, metabolism, aging, and unresolved inflammation.

He has also expanded into colon cancer research togetherwith Dr. Timothy Yeatman of USF Morsani, investigating how dietary fats and failed resolution drive chronic disease.

Key Topics Covered:

”What SPMs (resolvins, lipoxins, maresins, protectins) are and how they actively drive resolution, clear debris, promote repair, and prevent fibrosis.

The spleen-heart axis and the central role of macrophages in cardiac healing.Impact of diet, omega-3/omega-6 balance, seed oils, ultra-processed foods, obesity, aging, and other factors on SPM pathways.

Research on heart failure, cardiorenal syndrome, sex differences, and translational findings.

Recent and ongoing work linking unresolved inflammation and lipid dysregulation to colon cancer.

Future directions in resolution pharmacology and “resolution medicine.

Resources Mentioned:

The lab of Dr. Halade

https://2102045666.github.io/HaladeLab/index.html

USF Health Heart Institute – Dr. Ganesh Halade faculty profile

https://health.usf.edu/medicine/heart-institute/faculty/ghalade

Dr. Halade's landmark Lancet paper on SPM in cardiac repair and heart failure

https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(22)00176-1/fulltext

Paper on Colon Cancer together with Dr. TimothyYeatman

https://www.usf.edu/news/2024/how-ultra-processed-foods-may-drive-colorectal-cancer-risk.aspx

Professor Jesmond Dalli: Decoding Specialized Pro-Resolving Mediators (SPMs) – From Marine Biology to Resolution Pharmacology

In this episode of the SPM Podcast, host we welcome Professor Jesmond Dalli, a leading expert in the field of resolution pharmacology and specialized pro-resolving mediators (SPMs).

Dr. Dalli is Professor of Molecular Pharmacology at the Barts and The London School of Medicine and Dentistry, Queen Mary University of London. He directs the Dalli Lab (also known as the Lipid Mediator Unit) at the William Harvey Research Institute, the Lab is called the "jdallilab"

His research team focuses on the biology of specialized pro-resolving mediators (SPMs) — including resolvins, protectins, and maresins — and their critical roles in regulating innate immunity, promoting tissue repair and regeneration, resolving inflammation, and restoring homeostasis without impairing host defense.

The work has significant therapeutic implications for chronic inflammatory diseases, cardiovascular conditions, arthritis, infections, and impaired healing.

Guest Background Dr Jesmond Dalli

education: Bachelor of Science in Chemistry and Biology, followed by a Master of Science in Biology (with marine biology focus) from the University of Malta.

PhD: Completed at the William Harvey Research Institute, Queen Mary University of London, under Professor Mauro Perretti, focusing on the molecular pharmacology of inflammation.

Postdoctoral training: Joined the lab of Professor Charles Serhan at Harvard Medical School and Brigham and Women’s Hospital in Boston. Rose to Instructor and co-directed NIH-funded lipid mediator metabolomics courses. This period deepened expertise in SPM discovery and actions.

Current role: Leads an independent research program back at Queen Mary University of London, with over 170 peer-reviewed publications in high-impact journals (e.g., Nature Medicine, Immunity, Science Translational Medicine).

Key contributions: Advancing "resolution pharmacology" — understanding how inflammation naturally ends and leveraging SPM pathways for new therapies.

Episode overview : The introduction highlights Dr. Dalli as one of the key architects in the field, with personal anecdotes about his journey from Malta, career moves, mentors, and transition from marine biology interests to lipid mediator research.

Topics covered include: Core Science of SPMs: What SPMs are (resolvins, protectins, maresins, etc.), their mechanisms (reprogramming cellular responses to resolve inflammation actively rather than suppress it), promotion of tissue regeneration, bacterial clearance in specific contexts, and restoration of homeostasis.

Emphasis on them as positive regulators that balance inflammation without compromising defense.

Broader Biological Impact: Beyond acute inflammation resolution — roles in maintaining health/homeostasis in tissues even without overt inflammation; potential in chronic diseases.

Research Philosophy & Future Directions: SPMs as context-specific mediators; ongoing work on homeostasis; therapeutic potential ("resolution pharmacology").

Supplements and the use of AI in SPM science Ending on a personal note.

These topics make the episode valuable for researchers, clinicians, or anyone interested in inflammation resolution, lipid mediators, and translational medicine.

Dr. Jesmond Dalli is a top voice in the field of bioactive lipids especially Specialized pro resolving mediators.

Lab Resources Website: jdallilab.com (or www.jdallilab.com)

X handle: @jdallilab