Why Cannabis Affects Everyone Differently: How Genetics Shape Your Response to THC & CBD with Len May
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What if your DNA could explain why certain medications work for you, why stress affects you differently, or why one cannabis product helps one person but causes anxiety in another?
In this episode of Hormone Heroes, Dr. Kelly Hopkins sits down with Len May, CEO and co-founder of EndoDNA, to explore the rapidly evolving world of personalized medicine, cannabis genetics, epigenetics, functional medicine, ADHD, and AI-driven healthcare.
Len shares how his personal experience with ADD eventually led him into cannabis genomics, biotechnology, and precision wellness.
Together, Dr. Kelly and Len break down the science of the endocannabinoid system and explain how genetics influence the way the body responds to THC, CBD, stress, inflammation, hormones, supplements, medications, dopamine, and overall health.
The conversation explores why cannabis affects every individual differently, how CYP450 enzymes influence cannabis metabolism, why some people react strongly to gummies and edibles, and why the traditional Indica vs. Sativa conversation is often misleading. Len also explains how personalized wellness protocols based on DNA testing, epigenetics, biomarkers, and lifestyle medicine may help reduce adverse reactions and improve long-term health outcomes.
Beyond cannabis science, this episode dives into neurodivergence, entrepreneurship, dopamine regulation, high performance, stress physiology, hormone health, inflammation, biohacking, root-cause healing, and the future of AI-powered precision healthcare.
Key Topics Covered:
- The endocannabinoid system and its role in mood, stress response, inflammation, hormones, gut health, and homeostasis
- How THC, CBD, CB1 receptors, and CB2 receptors affect the brain and body
- Why genetics influence cannabis experiences and adverse reactions
- CYP450 enzymes, cannabis metabolism, gummies, tinctures, and personalized dosing
- The science behind terpenes and why Indica vs. Sativa is outdated
- ADHD, dopamine regulation, neurodivergence, and entrepreneurship
- Functional medicine, root-cause healthcare, and personalized wellness
- Genomics, epigenetics, biomarker tracking, and AI-driven healthcare platforms
- Hormone optimization, stress physiology, inflammation, and longevity
- How EndoDNA uses DNA testing and precision medicine to create individualized wellness protocols
This episode is a fascinating look into cannabis science, personalized medicine, human optimization, and the future of holistic healthcare.
If you found value in this episode, please subscribe and leave a 5-star review. It helps others find these root-cause health insights!
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Website: https://podcast.hormoneheroes.org/2396932
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Len May's Website: https://www.lenmaycoaching.com/
LinkedIn: https://www.linkedin.com/in/lenmay/
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Instagram: https://www.instagram.com/lenmaydna/
YouTube: https://www.youtube.com/channel/UCnAT1PJgjSYFwL7hAtnJUng
About the Podcast:
Hormone Heroes with Dr. Kelly Hopkins brings inspiring patient stories and expert conversations about hormone health. Each week, Dr. Hopkins, a functional medicine practitioner and hormonal wellness specialist interviews men and women whose lives have changed after bio-identical hormone therapy, along with leading functional medicine practitioners
Disclaimer: This podcast is for educational purposes only. Always consult a healthcare provider.
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