Where Did the Simufilam Data Vanish? The Filamin A Mystery
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Where Did the Simufilam Data Vanish? The Filamin A Mystery
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Hope for months of life was funded with sixteen million dollars in federal grants-yet investigators later found zero original data to support the mechanism behind simufilam. How did a drug program that enrolled hundreds, sparked four simultaneous investigations, and ended with the announcement “the drug did not work” come to rest on no surviving primary records?
In this episode, we tell the story of the filamin A hypothesis and the simufilam program, tracing how a single laboratory’s data became the foundation for clinical trials and multimillion-dollar NIH funding. What exactly vanished from the record, and what does that mean for the patients and science that relied on it?
Person: Hoau-Yan Wang
Person: Lindsay Burns
Institution: City University of New York (CUNY)
Company: Pain Therapeutics / Cassava Sciences
Amount: $16,000,000
- The NIH funding related to this program totaled sixteen million dollars.
- The filamin A mechanism was primarily reported by one lab led by Hoau-Yan Wang.
- Foundational papers on filamin A’s role were published in 2008 and 2009 in PLOS One.
- By March 2020 Cassava Sciences launched open-label studies of simufilam with enrolled patients.
- The program ended on November 25, 2024 with the announcement that the drug did not work.
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