When a Lab Vanished: The Simufilam Data That Disappeared
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When a Lab Vanished: The Simufilam Data That Disappeared
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Hope turned into doubt when a western blot printout showed identical background pixels across distinct wells - a kind of precision biology never makes - and the missing original data that could have explained it vanished. This episode unravels how a single lab's images helped secure $16 million in federal support and enroll 400 patients in a Phase III trial, and asks: what happens when the evidence that built a drug disappears?
In this episode, we trace the story of simufilam from early papers and NIH funding to conflicting biomarker results and federal investigations, following the questions left by images, labs, and late-night doors closing. What did the missing source data mean for a drug that promised to reset the protein FLNA and slow Alzheimer's?
Person: Hoau‑Yan Wang
Person: Lindsay Burns
Company: Cassava Sciences
Grant: more than $16,000,000
Trial enrollment: 400 patients
- A western blot printout showed identical background pixel regions where biological noise should have differed.
- The Journal of Neuroscience published a 2012 paper on the proposed mechanism involving filamin A (FLNA).
- Neurobiology of Aging published a 2017 paper reporting benefit in an Alzheimer's mouse model.
- The National Institutes of Health awarded a grant in 2018 that became part of over $16 million in federal support.
- In May 2020 a biomarker analysis indicated the drug was not working, and in September 2020 Cassava announced an outside lab found improvements.
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