When Dr. Lara Jehi began treating epilepsy patients in the 2000s, critical surgical decisions were driven more by clinician intuition and expertise than data. Today, she is a leader of IBM and Cleveland Clinic’s Discovery Accelerator, using advanced AI and quantum computing to transform how researchers analyze data, simulate molecules, accelerate drug discovery, and develop more precise treatments. Malcolm Gladwell talks with Dr. Jehi about how quantum computing is changing biomedical research, and what these breakthroughs could mean for the future of healthcare and life sciences.

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Nir Barzilai is a physician and a researcher at the Albert Einstein College of Medicine in New York, where he runs the Institute for Geroscience. Nir’s problem is this: How can we use lifestyle changes and drugs to slow the process of aging?

In this episode, Nir explains:

• The search for biological markers of aging
• The existing drugs that might reduce the risk of diseases associated with aging
• The four key lifestyle factors that every researcher in the field agrees on
• What he learned by studying the genes of people who lived to 100
• What “geroscience” means, and why it doesn’t have a Wikipedia page

Connect with us:

• Follow Jacob Goldstein on LinkedIn, X and Instagram
• Email us at problem@pushkin.fm
• Follow Pushkin on Instagram, LinkedIn or X
• Listen to Jacob’s other show, Business History
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Helen Pearson is the author of the book “Beyond Belief: How Evidence Shows What Really Works.” Helen's problem is this: How do you get people to make important decisions based on high-quality evidence, instead of on hunches or habits?

In this episode, Helen explains:

• How a doctor's fatal mistake sparked the evidence-based medicine movement
• Why management is so resistant to evidence-based practices
• How systematic reviews changed the way she works as a science journalist
• Why global trust in science remains high – outside the US
• What a randomized trial of pint glasses revealed about preventing violent injuries.

Check out Helen’s book here.

Connect with us:

• Follow Jacob Goldstein on LinkedIn, X and Instagram
• Email us at problem@pushkin.fm
• Follow Pushkin on Instagram, LinkedIn or X
• Listen to Jacob’s other show, Business History
• To listen to the show early and ad free, sign up for Pushkin+

See omnystudio.com/listener for privacy information.