In this episode of An Hour of Innovation podcast, host Vit Lyoshin sits down with Spiros Xanthos, Founder and CEO of Resolve AI, to explore how artificial intelligence is transforming the world of DevOps, observability, and software reliability.

Spiros shares how Resolve AI is building autonomous AI agents that act like site reliability engineers, capable of troubleshooting incidents, detecting root causes, and even generating pull requests to fix issues before they escalate. The conversation delves into how AI automation is redefining what it means to be an engineer, the evolving trust relationship between humans and AI, and the technical challenges of creating systems that are smart enough to operate in complex production environments. Spiros also opens up about his entrepreneurial journey as a serial founder, his lessons from building multiple startups, and why Resolve AI is the hardest and most rewarding company he’s ever built.

Spiros Xanthos is a serial entrepreneur, technologist, and innovator in the observability and AI DevOps space. Before founding Resolve AI, he co-founded Omnition, which was acquired by Splunk, and Log Insight, which was acquired by VMware. He’s also one of the co-creators of OpenTelemetry, the open-source standard for telemetry data that powers modern observability systems. Today, as CEO of Resolve AI, Spiros leads a team that’s pioneering AI-driven reliability engineering, combining deep observability expertise with cutting-edge AI research to build self-healing software systems.

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Takeaways

* AI is moving beyond code generation; it’s now running and maintaining production systems.

* The biggest challenge in AI DevOps isn’t data, it’s reasoning across code, logs, and systems.

* Trust is earned; AI systems must prove reliability through transparency and evidence.

* AI can make safe, reversible changes autonomously, reducing human fatigue and error.

* The hardest part of building Resolve AI was teaching AI to reason like an engineer.

* Spiros believes AI won’t replace engineers; it will create more of them by automating repetitive work.

* The role of engineers will shift from coding to directing and orchestrating AI agents.

* Many current DevOps tools were built for humans; the next generation must be agent-first.

* Founders should practice radical transparency to build trust and alignment in their teams.

* Psychological safety and risk-taking are essential for innovation in AI startups.

* Even without a product, talking to users and showing prototypes accelerates validation.

* The future of software is self-healing, intelligent, and AI-managed systems.

* Every product in the next decade will have an AI-first version or be replaced by one.

Timestamps

00:00 Introduction: AI and the Future of Software

05:08 Resolve AI vs Other AI Tools

07:36 Human Oversight in AI Decisions

09:12 Building Trust in AI Systems

10:53 Challenges in AI Development

14:19 Future of Software Engineering with AI

16:53 Unsolved Gaps in AI and DevOps

18:12 Industry Views on AI Automation

19:50 Lessons from Serial Entrepreneurship

23:01 Competing for AI Talent

23:54 Inside Fast-Moving AI Startups

25:52 Customer-Driven AI Product Development

27:46 Engaging Users Without a Product

29:49 Choosing the Right Startup Idea

32:18 Key Lessons for AI Entrepreneurs

34:26 Building Strong AI Teams

36:11 Funding and Growth in AI Startups

37:28 Future of AI in DevOps

39:08 Opportunities in the AI Revolution

41:51 Final Advice for Entrepreneurs

Connect with Spiros

* Website: https://resolve.ai/

* LinkedIn: https://www.linkedin.com/in/spiros/

* X: https://x.com/spirosx

Connect with Vit

* LinkedIn: https://www.linkedin.com/in/vit-lyoshin/

* X: https://x.com/vitlyoshin

Vit’s Projects

* Podcast: https://www.anhourofinnovation.com/

* AI Assistant to build apps: https://appforgelab.com/

In this episode of An Hour of Innovation podcast, host Vit Lyoshin sits down with Rob LoCascio, founder of LivePerson and creator of Uare.ai (Formerly Eternos), to explore how artificial intelligence can be used not to replace us, but to remember us.

Rob shares the fascinating story behind his company building AI avatars that capture your voice, knowledge, and decision-making patterns to create a deeply personal digital version of you. They discuss the emotional first test case of a terminally ill man who spoke with his AI self, the future of human-centered AI, and what it means to leave a lasting digital legacy. The conversation also dives into Rob’s journey from inventing web chat in 1997 to pioneering conversational AI, his lessons from decades as an entrepreneur, and his vision for ethical, purpose-driven innovation.

Rob LoCascio is a visionary tech entrepreneur best known as the founder and former CEO of LivePerson, the company that introduced real-time web chat to the internet. After nearly three decades leading innovation in customer experience and AI, he launched Uare.ai (Formerly Eternos), an AI platform focused on preserving human stories and memories through personalized AI models.

Support This Podcast

* To support our work, please check out our sponsors and get discounts: https://www.anhourofinnovation.com/sponsors/

Takeaways

* Rob shares the emotional story of a man who recorded his life story and later spoke to his AI self, proving how technology can preserve human connection.

* The core idea behind Uare.ai (formerly Eternos): building human-centered AI that keeps our memories, wisdom, and emotions alive.

* Rob predicts that experts and professionals will soon have AI versions of themselves sharing their knowledge globally.

* Passing down wisdom through personal AI is more powerful than passing down money; it’s a new kind of legacy.

* Rob reflects on nearly 30 years as a founder and reminds entrepreneurs that building something meaningful isn’t easy, but it’s worth it.

Timestamps

00:00 Introduction

01:42 From LivePerson to Digital Immortality

08:32 How Personal AI Works: Capturing Your Voice, Memory, and Wisdom

12:09 The Inspiration: AI for Humanity, Not Replacement

15:03 Inside the Human Life Model: The Future of Human-Centered AI

19:49 Use Cases: How AI Serves Families and Experts

21:45 Ethics, Privacy, and Data Ownership in AI Legacy Systems

25:51 Passing Down Wisdom: Generational Knowledge as the New Legacy

34:36 Entrepreneurial Lessons from a 30-Year Journey

38:19 The Hard Truth About Startups and Resilience

40:54 The Future of AI: Building Connection and Community Through Technology

Connect with Rob

* Website: https://www.uare.ai/

* LinkedIn: https://www.linkedin.com/in/rlocascio/

* X: https://x.com/roblocascio

* Other: https://eternos.life/

Connect with Vit

* Website: https://vitlyoshin.com/contact/

* LinkedIn: https://www.linkedin.com/in/vit-lyoshin/

* X: https://x.com/vitlyoshin

Vit’s Projects

* Podcast: https://www.anhourofinnovation.com/

* AI Assistant to build apps: https://appforgelab.com/

In this episode of An Hour of Innovation podcast, host Vit Lyoshin sits down with Henry O’Connell, CEO and Co-Founder of Canary Speech, to explore how artificial intelligence is transforming healthcare through the power of the human voice.

Henry shares the fascinating story of how a simple conversation in a bagel shop led to the creation of a breakthrough technology that analyzes how we speak, not what we say, to detect early signs of neurological and mental health conditions such as Parkinson’s, Alzheimer’s, anxiety, and depression. We discuss how AI voice biomarkers work, how Canary Speech can process 15 million data points per minute, and how this innovation enables early disease detection through non-invasive, real-time speech analysis.

Henry also explains how this technology integrates with wearables and clinical tools, allowing doctors to monitor patients through their voice using smartphones, smartwatches, and telemedicine platforms. He reveals how machine learning models can recognize patterns invisible to the human ear, helping medical professionals diagnose faster, more accurately, and with greater empathy.

Beyond the technology, Henry shares his vision for the future of medicine, his passion for accessibility in global healthcare, and his lessons from building a company at the intersection of AI, neuroscience, and digital health innovation.

Henry O’Connell is a healthcare innovator and entrepreneur. As the CEO of Canary Speech, he leads a team pioneering the use of voice biomarkers for early detection of diseases that affect millions worldwide. His work has been published in The Lancet and recognized by global partners including Microsoft, Samsung, and Harvard’s Beth Israel Hospital. Under his leadership, Canary Speech is redefining how AI can listen, understand, and improve human health.

Support This Podcast

* To support our work, please check out our sponsors and get discounts: https://www.anhourofinnovation.com/sponsors/

Takeaways

* AI can now analyze how we speak, not what we say, to detect health conditions.

* The human voice contains over 2,500 measurable biomarkers tied to brain and body function.

* Canary Speech analyzes 15 million data points per minute from spoken language.

* Diseases like Parkinson’s, Alzheimer’s, anxiety, and depression can be detected early through voice.

* The central nervous system controls speech, making it a powerful source of diagnostic data.

* Voice biomarkers are universal; the same disease patterns appear across languages and cultures.

* The technology works through smartphones, telehealth systems, and even Samsung watches.

* Canary Speech partners with leading institutions like Harvard, Hackensack Meridian, and The Lancet.

* AI enables non-invasive, real-time health monitoring during normal conversations.

* The system can even detect stress, fatigue, and aggression, helping prevent hospital incidents.

* Voice-based diagnostics may one day redefine patient-doctor interactions.

Timestamps

00:00 Introduction

01:56 The Birth of Canary Speech

07:00 Can AI Hear Illness?

14:25 Inside Voice Biomarkers

22:21 Detecting Anxiety, Depression, and Cognitive Decline Through Speech

25:07 How AI Voice Technology Works in Real Healthcare Settings

26:29 Preventing Aggression and Protecting Care Teams

29:56 Giving Doctors a New Diagnostic Superpower

31:10 What Doctors Say?

32:17 Everyday Applications of Voice AI

34:57 Making AI-Driven Healthcare Accessible Worldwide

36:11 Data Privacy, Ethics, and Trust in AI Healthcare

38:49 Could We Talk to Animals?

42:00 Leadership, Failure, and Building with Purpose

Connect with Henry

* Website: https://canaryspeech.com/

* LinkedIn: https://www.linkedin.com/in/henryjoconnell/

Connect with Vit

* Website: https://vitlyoshin.com/contact/

* LinkedIn: https://www.linkedin.com/in/vit-lyoshin/

* X: https://x.com/vitlyoshin

Vit’s Projects

* Podcast: https://www.anhourofinnovation.com/

* AI Assistant to build apps: https://appforgelab.com/