We are gearing up for our annual AI in Drug Discovery summit in a few days. So, for this episode, we focused on some recent AI news coverage. First, GEN senior editor Fay Lin, PhD, visited Seattle recently for some AI-focused meetings. She discusses her experiences in the Emerald City including an exclusive in-person interview with Nobel laureate, David Baker, PhD, on what’s real and what’s hype when it comes to using AI to design proteins de novo.  Then we discuss new research from University of California, San Diego, that used machine learning to identify networks of genes that could be targeted to reprogram cancer stem cells. We also go over some early studies that point to a possible drug candidate for colon cancer.  

Join GEN editors Corinna Singleman, PhD, Fay Lin, PhD, and Uduak Thomas for a discussion of the latest biotech and biopharma news. 

Listed below are links to the GEN stories referenced in this episode of Touching Base: 

Brunkow, Ramsdell, Sakaguchi Win Nobel Prize in Physiology or Medicine for Peripheral Immune Tolerance 

Uduak Thomas, GEN, October 6, 2025 

AI in Protein Design: Hype vs. Reality Explained by David Baker 

By Fay Lin, PhD, GEN, October 20, 2025 

Nobel Anniversary: David Baker Keynotes STEM Fundraiser by ARCS Foundation Seattle 

By Fay Lin, PhD, GEN, October 14, 2025 

AI Treatment Reprograms and Triggers Cancer Stem Cells to Self-Destruct 

GEN, October 20, 2025 

The State of AI in Drug Discovery Registration 

Touching Base Podcast 

Hosted by Corinna Singleman, PhD 

Behind the Breakthroughs 

Hosted by Jonathan D. Grinstein, PhD

Hosted on Acast. See acast.com/privacy for more information.

Metal-organic frameworks and peripheral immune tolerance were the big winners of the Nobel prizes in chemistry, and in physiology or medicine, respectively. In this episode of the podcast, we discuss the winners and the impacts of their discoveries. Then we move over to some business news where we discuss a novel gene therapy for Huntington’s disease from uniQure that made waves recently. Early clinical trial data for AMT-130 showed that it could meaningfully slow the progression of the disease by as much as 75%. Also in business news, a new partnership involving Arbor Biotechnologies and Chiesi Group aims to develop gene editing therapies to target rare liver diseases.

Join GEN editors Corinna Singleman, PhD, Alex Philippidis, and Uduak Thomas for a discussion of the latest biotech and biopharma news.

Listed below are links to the GEN stories referenced in this episode of Touching Base:

Brunkow, Ramsdell, Sakaguchi Win Nobel Prize in Physiology or Medicine for Peripheral Immune Tolerance

Uduak Thomas, GEN, October 6, 2025

Metal-Organic Frameworks Win the 2025 Nobel Prize in Chemistry

Julianna LeMieux, PhD, GEN, October 8, 2025

Gene Therapy Significantly Slows Huntington Disease Progression

GEN, September 24, 2025

StockWatch: uniQure Shares Reach Five-Year High on “Game Changing” Huntington’s Data

Alex Philippidis, GEN Edge, September 28, 2025

Chiesi, Arbor Target Rare Liver Diseases in Up-to-$2.1B Gene Editing Collaboration

Alex Philippidis, GEN Edge, October 8, 2025

Touching Base Podcast

Hosted by Corinna Singleman, PhD

Hosted on Acast. See acast.com/privacy for more information.

GEN has been at the forefront of biotech and bioprocessing news for over 40 years. Last week, editor in chief, John Sterling and deputy editor in chief, Julianna LeMieux, PhD, attended BioProcess International (BPI). This annual meeting is a hallmark event for GEN, where we attend talks, speak with a multitude of bioprocess companies, and keep up to date on the latest products and news for the year. John and Julianna discuss their experience at this year’s event. Additionally, GEN held its first ever client appreciation reception this year at BPI and Julianna describes the atmosphere.

Join GEN editors John Sterling, Julianna LeMieux, PhD, and Corinna Singleman, PhD for a discussion of the latest biotech and biopharma news.

Listed below are links to the GEN stories referenced in this episode of Touching Base:

Boston’s Bioprocessing Buzz: GEN Reports Live from BPI 2025

Julianna LeMieux, PhD and John Sterling, GEN, September 18, 2025

Top 10 U.S. Biopharma Clusters 2025

Alex Philippidis, GEN, August 1, 2025

Top 10 Contract Development and Manufacturing Organizations 2025

Alex Philippidis, GEN, September 15, 2025

Touching Base Podcast

Hosted by Corinna Singleman, PhD

Hosted on Acast. See acast.com/privacy for more information.