The Sic That Screamed: Half a Milligram, Full Psychedelic Mystery
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The Sic That Screamed: Half a Milligram, Full Psychedelic Mystery
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Half a milligram of quipazine is printed in the scientific record with a sic-an editor’s signal that the number looks wrong but was left as written-and that same tiny dose is reported to have produced a full psychedelic response. How could a compound that caused reliable nausea and blocked human testing also show unmistakable psychedelic markers in animals at doses supposedly far below prior thresholds?
In this episode, we trace the paper trail from a 1966 research optimism to animal head-twitch responses in 1977, primate vomiting reports, and stalled human trials halted by dose-limiting nausea, and we ask whether the anomalous half-milligram report is a clerical fluke, a hint of hidden pharmacology, or evidence that quipazine’s effects were never fully testable.
Person: James Winter
Date: 1966
Date: 1977
Compound: quipazine
Drug class: serotonin agonist
- The published report records a dose of 0.5 milligram with the editorial insertion "sic".
- In 1977, rodents exposed to quipazine produced the head-twitch response associated with psychedelics.
- Monkeys given quipazine showed agitation, disrupted motor patterns, altered social interaction, and projectile vomiting.
- Early human trials were limited by nausea, with a maximum tolerated dose recorded at 25 milligrams and no confirmed LSD-like effects below that ceiling.
- James Winter proposed in 1994 using ondansetron to block nausea and reveal quipazine’s potential psychoactive effects.
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