If you’ve ever wondered why pain can persist even after high-quality excision surgery, this episode is for you. In today’s class, I’m diving deep into the neuroscience of pain and taking a closer look at what’s really going on in the body when it comes to endometriosis.

I break down the mechanics of pain, why endometriosis diagnosis is so notoriously delayed, and how central sensitization keeps the nervous system on high alert, amplifying pain signals long after physical lesions are removed.

We’ll also cover the intricate link between systemic inflammation, hormonal shifts, and nervous system signaling, plus emerging research targeting these pathways.

In This Episode, We Discuss:

• The Neuroscience of Pain: The distinct types of pain mechanisms and how your nervous system actually processes them.
• The Diagnostic Gap: Why endometriosis remains so complex to diagnose and why answers often take years to get.
• Nervous System Sensitization: How hyper-responsive neural pathways amplify pain and keep it around even post-surgery.
• Inflammation & Hormones: How cyclic hormonal shifts and chronic inflammation continuously feed into pain loops.
• Rewiring the Signal: Emerging therapies like vagus nerve stimulation and practical tools to down-train the nervous system.

Resources from Class

Insight Timer App

Kimberly Snyder Meditations

HeartAlign Meditation

Further Reading

Neurogenic Inflammation in the Context of Endometriosis—What Do We Know?

Reduced vagal tone in women with endometriosis and auricular vagus nerve stimulation as a potential therapeutic approach

Unravelling the Intricate Link: Mast Cells and Estrogen-Induced Pain Sensitization in Endometriosis