The Molecule That Mimicked LSD - But Made Humans Vomit First
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The Molecule That Mimicked LSD - But Made Humans Vomit First
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A molecule that behaved like LSD in every animal test still failed humans because the body rejected it first: quipazine produced full animal substitution and head-twitch responses, yet in primates and humans it provoked pronounced, persistent vomiting that made psychedelic effects irrelevant. How did a compound pass rigorous behavioral signatures for half a century and still never arrive in human consciousness?
In this episode, we trace quipazine’s unusual history through animal discrimination studies, primate trials, and the lone human reports, and ask whether the architectural clash between receptors explains the long puzzle. Could blocking one receptor have revealed the psychedelic effects that animals repeatedly signaled?
Person: James Winter
Date: 2007 (anonymous human report recorded; published 2011)
Date: 1994 (Winter’s proposal)
Topic: quipazine pharmacology
Event: doctoral thesis at Columbia University sealed until 2030
- Quipazine produced full substitution in drug discrimination studies trained on LSD, not partial or approximate.
- Quipazine reliably evoked the head-twitch response in mice, a key 5-HT2A activation marker.
- In primates, quipazine caused pronounced, persistent projectile vomiting linked to 5-HT3 activation.
- A human trial at 25 mg produced no LSD-like subjective effects and intolerable gastrointestinal side effects.
- A published document lists a 0.5 mg dose flagged with "sic," unexplained and anomalously low.
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