Matt introduces his series examining the complex relationship between sleep and cannabis, exploring both the historical context and contemporary scientific perspectives. The narrative begins with Dr. W.B. O'Shaughnessy's canine experiments in 1849, tracing the evolution to the foundational work on cannabis for sleep conducted by Drs. Clendinning and Bradbury. Despite anecdotal reports suggesting cannabis enhances sleep, the scenario is complicated by factors such as regulatory constraints, variable product quality, and the potential long-term health implications of cannabis usage.

In discussing the impact of cannabis on sleep, Matt elucidates the interactions among THC, CBD, and the endocannabinoid system. Initial benefits may include improved sleep onset and efficiency, but chronic use is often associated with negative outcomes such as increased nocturnal awakenings and reduced sleep quality in the latter half of the night. Additionally, Matt explores the challenges associated with discontinuing cannabis use, including the risk of THC dependency for sleep induction, highlighting the necessity for evidence-based approaches and individualized decision-making in using cannabis as a sleep aid.

Matt's analysis extends to the global context of cannabis consumption, advocating for well-informed choices amidst its growing popularity and the dynamic landscape of scientific research.

Please be aware that Matt is not a medical professional, and the content of this podcast should not be regarded as medical advice or as prescriptive in any manner.

This episode is sponsored by the Tim Ferriss Show, celebrating its ten-year anniversary with over 1 billion downloads since 2023. The show is renowned for Tim's profound interviews with a diverse range of guests—from Hollywood legends like Arnold Schwarzenegger and Jamie Foxx to lesser-known figures who have captivated Tim's attention—each episode is designed to offer deep insights and stimulate thoughtful discussions. Tune in to Tim.blog or look for the Tim Ferriss Show today, available wherever you find your podcasts.

The good people at InsideTracker are also one of the sponsors of this week's episode, and they are generously offering a special 25% off any one of their programs for anyone who uses the above link during the time window of this episode. InsideTracker is a personalized biometric platform that analyzes your blood and your DNA to better understand what's happening inside of you and offers suggestions regarding things that you can do to better try and adjust some of those numbers, optimize them, and, as a result, optimize you.

Another sponsor of the show is AG1, a comprehensive nutritional drink trusted by thousands worldwide, including Matt! For nearly four years and counting, he has relied on AG1 to fuel his post-workout routine with its powerhouse blend of over 75 essential minerals, vitamins, probiotics, and prebiotics, meticulously crafted to support your daily nutritional needs. AG1 is registered and approved by the Therapeuti

This week, Matt dives deep into the complexities of REM Sleep Behavior Disorder (RBD), a condition where individuals physically act out their dreams due to the absence of normal muscle paralysis during REM sleep. He meticulously breaks down the mechanisms of normal REM sleep, where the brainstem induces muscle atonia to prevent dream enactment, contrasting it with the failure of this system in RBD cases.

Further expanding on the topic, Matt explores the etiology, diagnosis, treatment options, and prognosis of REM Sleep Behavior Disorder. He outlines the primary, drug-induced, and secondary types of RBD, with a focus on the idiopathic category, linking its occurrence to neurodegeneration and the accumulation of alpha-synuclein protein in the brainstem. Treatment strategies include lifestyle adjustments and pharmacological interventions like melatonin and clonazepam, aiming to reduce injury risks.

Please note that Matt is not a medical doctor, and none of the content in this podcast should be considered medical advice in any way, shape, or form, nor prescriptive in any way.

Are sleep troubles keeping you up at night? Matt used to be a skeptic about meditation, but 7 years ago, he tried it using a fantastic meditation app called ‘Calm’, and it transformed his sleep! Now, he meditates for 10 minutes before bedtime every night! He’s also partnered with Calm who have been generous enough to offer his podcast listeners an exclusive 40% discount on their premium subscription! All you have to do is go to calm.com/mattwalker and take advantage of this incredible deal! Head on over now and improve your sleep today!

The good people at InsideTracker are one of the sponsors of this week's episode, and they are generously offering a special 25% off any one of their programs for anyone who uses the above link during the time window of this episode. InsideTracker is a personalized biometric platform that analyzes your blood and your DNA to better understand what's happening inside of you and offers suggestions regarding things that you can do to better try and adjust some of those numbers, optimize them, and, as a result, optimize you.

Another sponsor this week is the biochemical electrolyte drink company LMNT, and they are very kindly offering eight free sample packs when you purchase any one of their orders at drinklmnt.com/mattwalker. LMNT is an electrolyte sports drink that I can get behind - it's created from the basis of science, and it has no sugar, no coloring, and no artificial ingredients – all qualities that are so important to maintaining your blood biochemical balance. If you want to give LMNT a try, just head on over to drinklmnt.com/mattwalker and get your eight free samples with your first purchase.

Eti is back for another AMA episode with Matt to answer questions that have been submitted over the last little while. Today’s installment dives into a number of topics including the intricate relationship between sleep and pregnancy, exploring how sleep disturbances impact pregnant women and the postnatal period. Additionally, the hormone prolactin, essential for milk production, is highlighted for its sleep-promoting benefits during the postnatal phase, illustrating nature's intricate balance between nurturing new life and ensuring the mother's rest.

Their discussion also touches on whether pregnancy sleep disturbances are all part of preparing mom for baby’s arrival which, of course, can further disrupt schedules, citing the very few biological exceptions where sleep is actually sacrificed for survival. Our experts also undertake a light-hearted exploration of "eye gunk" (rheum), demystifying its composition and reassurance that its presence is a normal part of sleep hygiene rather than an indicator of sleep quality. They finish up by responding to a question regarding the connection between sex, masturbation, and sleep, which you absolutely do not want to miss.

Tune in today, and don’t forget to send in any sleep questions you may have - Matt and Eti might just answer them in a future episode!

Please note that Matt is not a medical doctor, and none of the content in this podcast should be considered medical advice in any way, shape, or form, nor prescriptive in any way.

One of the podcast’s new sponsors is Levels, the groundbreaking continuous glucose monitor that keeps track of your blood sugar levels day and night. Whether you're curious about your body's response to different foods or seeking to enhance your sleep quality, Levels has the answers. Matt’s been using it for almost 2 years now, and has actually made changes to his diet in response to the powerful individual information Levels provides. If you’re interested, visit levels.link/Mattwalker now to grab an exclusive podcast offer of two free months of this impactful service, and take charge of your health journey today!

Another exciting new sponsor is MUD\WTR, the ultimate coffee alternative that delivers a natural morning pick-me-up without caffeine jitters. Their unique blend of cacao and mushrooms offers a delightful and gentle lift to kickstart your day, as Matt can attest! Plus, now when you head over to mudwtr.com/MattWalker, as a podcast listener, you'll receive a free frother and coconut creamer samples! Experience the delicious world of MUD\WTR, valued sponsors of our podcast, and elevate your mornings with this fantastic offer!

As always, if you have thoughts or feedback you’d like to share, please rea